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CEACAM5 carcinoembryonic antigen related cell adhesion molecule 5 [ Homo sapiens (human) ]

Gene ID: 1048, updated on 15-Apr-2019

Summary

Official Symbol
CEACAM5provided by HGNC
Official Full Name
carcinoembryonic antigen related cell adhesion molecule 5provided by HGNC
Primary source
HGNC:HGNC:1817
See related
Ensembl:ENSG00000105388 MIM:114890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEA; CD66e
Summary
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Biased expression in colon (RPKM 540.8), appendix (RPKM 102.3) and 2 other tissues See more
Orthologs

Genomic context

See CEACAM5 in Genome Data Viewer
Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (41708585..41730433)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42212530..42234437)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372405 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 7 Neighboring gene uncharacterized LOC112268252 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 6 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 1 pseudogene Neighboring gene carcinoembryonic antigen related cell adhesion molecule 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystem (from REACTOME)
    Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystemGlycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactio...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781M2392

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GPI anchor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IC
Inferred by Curator
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 5
Names
meconium antigen 100

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291484.2NP_001278413.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001278413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Both variants 1 and 2 encode isoform 1.
    Source sequence(s)
    AC243967, AK223101, BP272354, BP272370, DB006625, M29540
    Consensus CDS
    CCDS12584.1
    UniProtKB/Swiss-Prot
    P06731
    UniProtKB/TrEMBL
    A0A024R0K5, Q53G30
    Related
    ENSP00000385072.1, ENST00000405816.5
    Conserved Domains (5) summary
    cd05740
    Location:324412
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:502590
    Ig; Immunoglobulin domain
  2. NM_001308398.1NP_001295327.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site at an internal exon and differs in the 3' UTR compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK223101, BP272354, BP272370, DB006625, X16455
    Consensus CDS
    CCDS77302.1
    UniProtKB/Swiss-Prot
    P06731
    UniProtKB/TrEMBL
    Q53G30
    Conserved Domains (5) summary
    cd05740
    Location:323411
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:501589
    Ig; Immunoglobulin domain
  3. NM_004363.5NP_004354.3  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_004354.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC243967, BP272354, BP272370, DB006625, M15042
    Consensus CDS
    CCDS12584.1
    UniProtKB/Swiss-Prot
    P06731
    UniProtKB/TrEMBL
    A0A024R0K5
    Related
    ENSP00000221992.5, ENST00000221992.10
    Conserved Domains (5) summary
    cd05740
    Location:324412
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:502590
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    41708585..41730433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026145.2XP_016881634.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X1

    Related
    ENSP00000381600.4, ENST00000398599.8
    Conserved Domains (5) summary
    cd05740
    Location:323411
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:501589
    Ig; Immunoglobulin domain
  2. XM_017026146.2XP_016881635.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X2

    Related
    ENSP00000482157.1, ENST00000615021.4
  3. XM_011526322.2XP_011524624.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X3

    Conserved Domains (5) summary
    cd05740
    Location:146234
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:324412
    Ig; Immunoglobulin domain
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