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IKZF1 IKAROS family zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 10320, updated on 9-Apr-2019

Summary

Official Symbol
IKZF1provided by HGNC
Official Full Name
IKAROS family zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:13176
See related
Ensembl:ENSG00000185811 MIM:603023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
Summary
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Expression
Biased expression in lymph node (RPKM 13.3), appendix (RPKM 8.6) and 10 other tissues See more
Orthologs

Genomic context

See IKZF1 in Genome Data Viewer
Location:
7p12.2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (50303453..50405101)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (50344378..50367358) , (50444231..50472799)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zona pellucida binding protein Neighboring gene G protein nucleolar 2 pseudogene 1 Neighboring gene spermatogenesis associated 48 Neighboring gene conserved acetylation island sequence 3 enhancer Neighboring gene RNA, U6 small nuclear 1091, pseudogene Neighboring gene fidgetin like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Immunodeficiency, common variable, 13
MedGen: C4225173 OMIM: 616873 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
NHGRI GWA Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
NHGRI GWA Catalog
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
NHGRI GWA Catalog
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Ikaros is identified to interact with HIV-1 Tat in Jurkat cell by GST pull-down and by WB PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterooligomerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
DNA-binding protein Ikaros
Names
CLL-associated antigen KW-6
ikaros family zinc finger protein 1
lymphoid transcription factor LyF-1
protein phosphatase 1, regulatory subunit 92
zinc finger protein, subfamily 1A, 1 (Ikaros)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034231.1 RefSeqGene

    Range
    5634..106019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001220765.2NP_001207694.1  DNA-binding protein Ikaros isoform 2

    See identical proteins and their annotated locations for NP_001207694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as Ikx) is shorter than isoform 1, and it contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963). Both variants 2 and 14 encode isoform 2.
    Source sequence(s)
    AY377974, BC018349, BM148203, DB148957, JX459579
    Consensus CDS
    CCDS59055.1
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Related
    ENSP00000352123.5, ENST00000359197.9
    Conserved Domains (2) summary
    sd00017
    Location:119139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001220767.2NP_001207696.1  DNA-binding protein Ikaros isoform 4

    See identical proteins and their annotated locations for NP_001207696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (4, also known as Ik-2(del) as described in PMID:9892693) is shorter than isoform 1. This isoform contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
    Source sequence(s)
    JX459579, U40462
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Conserved Domains (2) summary
    COG5048
    Location:1131
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6080
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001220768.2NP_001207697.1  DNA-binding protein Ikaros isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (5, also known as Ik-3 as described in PMID:12937159) is shorter than isoform 1. This isoform contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
    Source sequence(s)
    JX459579, U40462
    Consensus CDS
    CCDS75597.1
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Related
    ENSP00000349928.4, ENST00000357364.8
    Conserved Domains (2) summary
    sd00017
    Location:119139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001220770.2NP_001207699.1  DNA-binding protein Ikaros isoform 7

    See identical proteins and their annotated locations for NP_001207699.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in both the 5' and central coding regions, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (7, also known as Ik-4(del) as described in PMID:9892693), is shorter than isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
    Source sequence(s)
    JX459579, U40462
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Conserved Domains (3) summary
    COG5048
    Location:1112
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6080
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:7297
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001220771.2NP_001207700.1  DNA-binding protein Ikaros isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks three consecutive alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (8, also known as Ik-5 as described in PMID:12937159) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform.
    Source sequence(s)
    BC018349, JX459579
    Consensus CDS
    CCDS69299.1
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Related
    ENSP00000342485.4, ENST00000349824.8
  6. NM_001291837.1NP_001278766.1  DNA-binding protein Ikaros isoform 2

    See identical proteins and their annotated locations for NP_001278766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as Ikx) is shorter than isoform 1, and it contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963). Both variants 2 and 14 encode isoform 2.
    Source sequence(s)
    BC018349, DB122945, JX459579
    Consensus CDS
    CCDS59055.1
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Related
    ENSP00000413025.1, ENST00000439701.2
    Conserved Domains (2) summary
    sd00017
    Location:119139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001291838.1NP_001278767.1  DNA-binding protein Ikaros isoform 3

    See identical proteins and their annotated locations for NP_001278767.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Ik-2) differs in the 5' UTR, and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3, also known as Ik-2) is shorter than isoform 1, and is localized to the nucleus and contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
    Source sequence(s)
    AK303586, DB122945, JX459579
    Consensus CDS
    CCDS78233.1
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Related
    ENSP00000396554.1, ENST00000438033.5
    Conserved Domains (2) summary
    COG5048
    Location:1131
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6080
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001291839.1NP_001278768.1  DNA-binding protein Ikaros isoform 6

    See identical proteins and their annotated locations for NP_001278768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Ik-4) differs in the 5' UTR, and lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (6, also known as Ik-4 as described in PMID:12937159), is shorter than isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
    Source sequence(s)
    BC018349, DC391353, JX459579
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Conserved Domains (4) summary
    COG5048
    Location:1112
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6080
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:5880
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:7297
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001291840.1NP_001278769.1  DNA-binding protein Ikaros isoform Ik-6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Ik-6) lacks four consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-6) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, is localized to the cytoplasm and functions as a non-DNA-binding, dominant-negative isoform (PMIDs:12937159, 10463586).
    Source sequence(s)
    JX459579, U40462
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
  10. NM_001291841.1NP_001278770.1  DNA-binding protein Ikaros isoform Ik-7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Ik-7) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-7) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
    Source sequence(s)
    JX459579, U40462
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Related
    ENSP00000478368.1, ENST00000615491.4
    Conserved Domains (1) summary
    sd00017
    Location:6081
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. NM_001291842.1NP_001278771.1  DNA-binding protein Ikaros isoform Ik-7(del)

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Ik-7(del)) lacks two consecutive in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (Ik-7(del)) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
    Source sequence(s)
    JX459579, U40462
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Conserved Domains (1) summary
    sd00017
    Location:6081
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. NM_001291843.1NP_001278772.1  DNA-binding protein Ikaros isoform Ik-8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Ik-8) lacks three consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-8) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
    Source sequence(s)
    JX459579, U40462
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Related
    ENSP00000401507.3, ENST00000440768.6
  13. NM_001291844.1NP_001278773.1  DNA-binding protein Ikaros isoform Ik-8(del)

    Status: REVIEWED

    Description
    Transcript Variant: This variant (Ik-8(del)) lacks three consecutive in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (Ik-8(del)) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
    Source sequence(s)
    JX459579, U40462
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
  14. NM_001291845.1NP_001278774.1  DNA-binding protein Ikaros isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) lacks five 3' exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (15) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding.
    Source sequence(s)
    BC064594, DB148957
    Consensus CDS
    CCDS78232.1
    UniProtKB/TrEMBL
    C9JTB0
    Related
    ENSP00000388478.1, ENST00000413698.5
  15. NM_001291846.1NP_001278775.1  DNA-binding protein Ikaros isoform 16

    See identical proteins and their annotated locations for NP_001278775.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) lacks five 3' exons but contains two alternate 3' exons, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (16) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding. Both variants 16 and 17 encode isoform 16.
    Source sequence(s)
    AW337855, BM148203, BU537824, DB148957
    Consensus CDS
    CCDS87502.1
    Related
    ENSP00000493696.1, ENST00000646110.1
  16. NM_001291847.1NP_001278776.1  DNA-binding protein Ikaros isoform 16

    See identical proteins and their annotated locations for NP_001278776.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR, and lacks five 3' exons but contains two alternate 3' exons, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (16) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding. Both variants 16 and 17 encode isoform 16.
    Source sequence(s)
    AW337855, BU537824, DB122945
    Consensus CDS
    CCDS87502.1
    Related
    ENSP00000494180.1, ENST00000492782.6
  17. NM_006060.6NP_006051.1  DNA-binding protein Ikaros isoform 1

    See identical proteins and their annotated locations for NP_006051.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as Ik-1 as described in PMID:12937159). This isoform contains four N-terminal zinc finger motifs, binds DNA, and is localized to the nucleus.
    Source sequence(s)
    BM148203, JX459579, U40462
    Consensus CDS
    CCDS75596.1
    UniProtKB/Swiss-Prot
    Q13422
    UniProtKB/TrEMBL
    R9R4D9
    Related
    ENSP00000496453.1, ENST00000644005.1
    Conserved Domains (2) summary
    sd00017
    Location:119139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    50303453..50405101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515078.2XP_011513380.1  DNA-binding protein Ikaros isoform X15

    See identical proteins and their annotated locations for XP_011513380.1

    Conserved Domains (2) summary
    COG5048
    Location:25136
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011515059.3XP_011513361.1  DNA-binding protein Ikaros isoform X2

    See identical proteins and their annotated locations for XP_011513361.1

    Conserved Domains (3) summary
    COG5048
    Location:188262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:163183
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:176200
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011515067.3XP_011513369.1  DNA-binding protein Ikaros isoform X6

    See identical proteins and their annotated locations for XP_011513369.1

    Conserved Domains (2) summary
    sd00017
    Location:163183
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:176200
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011515074.2XP_011513376.1  DNA-binding protein Ikaros isoform X12

    See identical proteins and their annotated locations for XP_011513376.1

    Conserved Domains (2) summary
    COG5048
    Location:25155
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_011515070.2XP_011513372.1  DNA-binding protein Ikaros isoform X8

    See identical proteins and their annotated locations for XP_011513372.1

    Conserved Domains (2) summary
    sd00017
    Location:143163
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156180
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011515077.2XP_011513379.1  DNA-binding protein Ikaros isoform X14

    See identical proteins and their annotated locations for XP_011513379.1

    Conserved Domains (2) summary
    COG5048
    Location:25136
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_011515058.2XP_011513360.1  DNA-binding protein Ikaros isoform X1

    See identical proteins and their annotated locations for XP_011513360.1

    Conserved Domains (3) summary
    COG5048
    Location:187343
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:163183
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:176200
    zf-H2C2_2; Zinc-finger double domain
  8. XM_011515071.2XP_011513373.1  DNA-binding protein Ikaros isoform X9

    See identical proteins and their annotated locations for XP_011513373.1

    Conserved Domains (4) summary
    COG5048
    Location:101175
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:104124
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:102124
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:116141
    zf-H2C2_2; Zinc-finger double domain
  9. XM_011515061.3XP_011513363.1  DNA-binding protein Ikaros isoform X4

    See identical proteins and their annotated locations for XP_011513363.1

    Conserved Domains (3) summary
    COG5048
    Location:168242
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:143163
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:156180
    zf-H2C2_2; Zinc-finger double domain
  10. XM_011515072.2XP_011513374.1  DNA-binding protein Ikaros isoform X10

    See identical proteins and their annotated locations for XP_011513374.1

    Conserved Domains (2) summary
    COG5048
    Location:25155
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_011515076.2XP_011513378.1  DNA-binding protein Ikaros isoform X13

    See identical proteins and their annotated locations for XP_011513378.1

    UniProtKB/Swiss-Prot
    Q13422
    Conserved Domains (2) summary
    COG5048
    Location:1131
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6080
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_011515065.2XP_011513367.1  DNA-binding protein Ikaros isoform X5

    See identical proteins and their annotated locations for XP_011513367.1

    Conserved Domains (2) summary
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152176
    zf-H2C2_2; Zinc-finger double domain
  13. XM_017011669.1XP_016867158.1  DNA-binding protein Ikaros isoform X16

  14. XM_017011668.1XP_016867157.1  DNA-binding protein Ikaros isoform X13

    UniProtKB/Swiss-Prot
    Q13422
    Conserved Domains (2) summary
    COG5048
    Location:1131
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6080
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. XM_011515063.2XP_011513365.1  DNA-binding protein Ikaros isoform X5

    See identical proteins and their annotated locations for XP_011513365.1

    Conserved Domains (2) summary
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152176
    zf-H2C2_2; Zinc-finger double domain
  16. XM_017011667.1XP_016867156.1  DNA-binding protein Ikaros isoform X11

    Conserved Domains (3) summary
    sd00017
    Location:80100
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:78100
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:92117
    zf-H2C2_2; Zinc-finger double domain
  17. XM_011515068.2XP_011513370.1  DNA-binding protein Ikaros isoform X7

    See identical proteins and their annotated locations for XP_011513370.1

    UniProtKB/Swiss-Prot
    Q13422
    Conserved Domains (2) summary
    sd00017
    Location:119139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  18. XM_017011670.1XP_016867159.1  DNA-binding protein Ikaros isoform X16

  19. XM_011515066.2XP_011513368.1  DNA-binding protein Ikaros isoform X5

    See identical proteins and their annotated locations for XP_011513368.1

    Conserved Domains (2) summary
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152176
    zf-H2C2_2; Zinc-finger double domain
  20. XM_011515062.2XP_011513364.1  DNA-binding protein Ikaros isoform X5

    See identical proteins and their annotated locations for XP_011513364.1

    Conserved Domains (2) summary
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152176
    zf-H2C2_2; Zinc-finger double domain
  21. XM_011515073.2XP_011513375.1  DNA-binding protein Ikaros isoform X11

    Conserved Domains (3) summary
    sd00017
    Location:80100
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:78100
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:92117
    zf-H2C2_2; Zinc-finger double domain
  22. XM_011515075.2XP_011513377.1  DNA-binding protein Ikaros isoform X13

    See identical proteins and their annotated locations for XP_011513377.1

    UniProtKB/Swiss-Prot
    Q13422
    Related
    ENSP00000342750.5, ENST00000343574.9
    Conserved Domains (2) summary
    COG5048
    Location:1131
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:6080
    ZF_C2H2; C2H2 Zn finger [structural motif]
  23. XM_011515064.3XP_011513366.1  DNA-binding protein Ikaros isoform X5

    See identical proteins and their annotated locations for XP_011513366.1

    Conserved Domains (2) summary
    sd00017
    Location:139159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152176
    zf-H2C2_2; Zinc-finger double domain
  24. XM_011515069.2XP_011513371.1  DNA-binding protein Ikaros isoform X7

    See identical proteins and their annotated locations for XP_011513371.1

    UniProtKB/Swiss-Prot
    Q13422
    Conserved Domains (2) summary
    sd00017
    Location:119139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  25. XM_011515060.2XP_011513362.1  DNA-binding protein Ikaros isoform X3

    See identical proteins and their annotated locations for XP_011513362.1

    Conserved Domains (3) summary
    COG5048
    Location:174248
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:149169
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:162186
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001220766.1: Suppressed sequence

    Description
    NM_001220766.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NM_001220769.1: Suppressed sequence

    Description
    NM_001220769.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  3. NM_001220772.1: Suppressed sequence

    Description
    NM_001220772.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_001220773.1: Suppressed sequence

    Description
    NM_001220773.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  5. NM_001220774.1: Suppressed sequence

    Description
    NM_001220774.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  6. NM_001220775.1: Suppressed sequence

    Description
    NM_001220775.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  7. NM_001220776.1: Suppressed sequence

    Description
    NM_001220776.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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