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OLIG2 oligodendrocyte transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 10215, updated on 15-Apr-2019

Summary

Official Symbol
OLIG2provided by HGNC
Official Full Name
oligodendrocyte transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:9398
See related
Ensembl:ENSG00000205927 MIM:606386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19
Summary
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 29.0) See more
Orthologs

Genomic context

See OLIG2 in Genome Data Viewer
Location:
21q22.11
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (33025908..33029196)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34398216..34401504)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377136 Neighboring gene VISTA enhancer hs1188 Neighboring gene long intergenic non-protein coding RNA 1690 Neighboring gene uncharacterized LOC107985505 Neighboring gene uncharacterized LOC105372785 Neighboring gene long intergenic non-protein coding RNA 945

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
    Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
HMG box domain binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
myelination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
neuron fate commitment IEA
Inferred from Electronic Annotation
more info
 
positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
spinal cord oligodendrocyte cell fate specification IEA
Inferred from Electronic Annotation
more info
 
thalamus development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
oligodendrocyte transcription factor 2
Names
basic domain, helix-loop-helix protein, class B, 1
class B basic helix-loop-helix protein 1
class E basic helix-loop-helix protein 19
human protein kinase C-binding protein RACK17
oligodendrocyte lineage transcription factor 2
oligodendrocyte-specific bHLH transcription factor 2
protein kinase C-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011834.1 RefSeqGene

    Range
    4978..8266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005806.4NP_005797.1  oligodendrocyte transcription factor 2

    See identical proteins and their annotated locations for NP_005797.1

    Status: REVIEWED

    Source sequence(s)
    AF221520, BC047511
    Consensus CDS
    CCDS13620.1
    UniProtKB/Swiss-Prot
    Q13516
    Related
    ENSP00000371794.3, ENST00000382357.4
    Conserved Domains (1) summary
    smart00353
    Location:114168
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    33025908..33029196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260908.1XP_005260965.1  oligodendrocyte transcription factor 2 isoform X1

    See identical proteins and their annotated locations for XP_005260965.1

    UniProtKB/Swiss-Prot
    Q13516
    Related
    ENSP00000331040.3, ENST00000333337.3
    Conserved Domains (1) summary
    smart00353
    Location:114168
    HLH; helix loop helix domain
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