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EBI3 Epstein-Barr virus induced 3 [ Homo sapiens (human) ]

Gene ID: 10148, updated on 27-Nov-2024

Summary

Official Symbol
EBI3provided by HGNC
Official Full Name
Epstein-Barr virus induced 3provided by HGNC
Primary source
HGNC:HGNC:3129
See related
Ensembl:ENSG00000105246 MIM:605816; AllianceGenome:HGNC:3129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL27B; IL35B; IL-27B
Summary
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]
Expression
Biased expression in placenta (RPKM 82.3), spleen (RPKM 9.3) and 2 other tissues See more
Orthologs
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Genomic context

See EBI3 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4229523..4237528)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4210322..4220831)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4229520..4237525)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13760 Neighboring gene sirtuin 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13761 Neighboring gene ankyrin repeat domain 24 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4199326-4199972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4199973-4200619 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4204935-4205148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4216177-4216676 Neighboring gene MPRA-validated peak3273 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4230793-4231294 Neighboring gene MPRA-validated peak3276 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4246137-4246908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13766 Neighboring gene YJU2 splicing factor homolog Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9883 Neighboring gene Src homology 2 domain containing transforming protein D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of Epstein-Barr virus induced 3 (EBI3, IL-27B) in human primary T cells PubMed
Vpr vpr HIV-1 Vpr downregulates the expression of EBI3 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables interleukin-27 receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
interleukin-27 subunit beta
Names
EBV-induced gene 3 protein
Epstein-Barr virus induced gene 3
IL-27 subunit beta
IL27 subunit
IL35 subunit
cytokine receptor
epstein-Barr virus-induced gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005755.3NP_005746.2  interleukin-27 subunit beta precursor

    See identical proteins and their annotated locations for NP_005746.2

    Status: REVIEWED

    Source sequence(s)
    AC005578
    Consensus CDS
    CCDS12123.1
    UniProtKB/Swiss-Prot
    A0N0N2, O75269, Q14213
    Related
    ENSP00000221847.4, ENST00000221847.6
    Conserved Domains (2) summary
    smart00060
    Location:47115
    FN3; Fibronectin type 3 domain
    cd00063
    Location:129224
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4229523..4237528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4210322..4220831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319494.1XP_054175469.1  interleukin-27 subunit beta isoform X1

    UniProtKB/Swiss-Prot
    A0N0N2, O75269, Q14213