-
ITS1 and cpb genetic polymorphisms in Algerian and Tunisian Leishmania infantum isolates from humans and dogs.
Title: ITS1 and cpb genetic polymorphisms in Algerian and Tunisian Leishmania infantum isolates from humans and dogs.
-
Genetic depletion of the RNA helicase DDX3 leads to impaired elongation of translating ribosomes triggering co-translational quality control of newly synthesized polypeptides.
Title: Genetic depletion of the RNA helicase DDX3 leads to impaired elongation of translating ribosomes triggering co-translational quality control of newly synthesized polypeptides.
-
Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan.
Title: Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan.
-
Leishmania dual-specificity tyrosine-regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype.
Title: Leishmania dual-specificity tyrosine-regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype.
-
Casein kinase 1.2 over expression restores stress resistance to Leishmania donovani HSP23 null mutants.
Title: Casein kinase 1.2 over expression restores stress resistance to Leishmania donovani HSP23 null mutants.
-
A single amino acid substitution (H451Y) in Leishmania calcium-dependent kinase SCAMK confers high tolerance and resistance to antimony.
Title: A single amino acid substitution (H451Y) in Leishmania calcium-dependent kinase SCAMK confers high tolerance and resistance to antimony.
-
Sequence analysis showed that LiMTAP shared higher identity rates with the Trypanosoma brucei (TbMTAP) and the human (huMTAP) homologs; the 3D model of LiMTAP showed an additional alpha-helix, at the C terminal extremity; study highlighted significant structural differences.
Title: Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.
-
Leishmania infantum LiSIR2rp1 was among the first non-nuclear and essential SIR2 deacetylases described in eukaryotes; study shows that the two other LiSIR2rp2 and LiSIRrp3 paralogs are both located in mitochondria. Further, genetic and biochemical evidence show that SIR2rp2 protein directly affects parasite proliferation in relation to NAD+ bioavailability. [SIR2rp2, SIRrp3]
Title: Functional divergence of SIR2 orthologs between trypanosomatid parasites.
-
The article reported that L. infantum ARM58 is part of a gene cluster conferring resistance to antimony at the telomeric end of chromosome 34, also comprising the neighboring genes ARM56 and HSP23. [ARM58], [ARM56], [HSP23]
Title: A Telomeric Cluster of Antimony Resistance Genes on Chromosome 34 of Leishmania infantum.
-
these observations support a central role for the Leishmania DDX3 homolog in preventing reactive oxygen species-mediated damage and in maintaining mitochondrial protein quality control.
Title: DDX3 DEAD-box RNA helicase plays a central role in mitochondrial protein quality control in Leishmania.