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    H2BC18 H2B clustered histone 18 [ Homo sapiens (human) ]

    Gene ID: 440689, updated on 21-Dec-2019

    Summary

    Official Symbol
    H2BC18provided by HGNC
    Official Full Name
    H2B clustered histone 18provided by HGNC
    Primary source
    HGNC:HGNC:24700
    See related
    Ensembl:ENSG00000203814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIST2H2BF
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in prostate (RPKM 4.3), appendix (RPKM 1.9) and 23 other tissues See more

    Genomic context

    See H2BC18 in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (149782689..149812373, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149754245..149783965, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 D4 (putative) pseudogene Neighboring gene tRNA-Arg (anticodon CCT) 8-1 Neighboring gene Fc fragment of IgG receptor Ia Neighboring gene uncharacterized LOC112268237 Neighboring gene H3 clustered histone 13 Neighboring gene H4 clustered histone 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, histone cluster 2, H2bf (HIST2H2BF), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ35099, FLJ56780, FLJ56787, MGC131639

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    molecular_function ND
    No biological Data available
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    extracellular exosome HDA PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus HDA PubMed 

    General protein information

    Preferred Names
    histone H2B type 2-F
    Names
    histone cluster 2 H2B family member f
    histone cluster 2, H2bf

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033089.1 RefSeqGene

      Range
      5001..34684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024599.5NP_001019770.1  histone H2B type 2-F isoform a

      See identical proteins and their annotated locations for NP_001019770.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' coding region and 3' UTR, compared to variant 2. The encoded isoform (a) has a shorter C-terminus compared to isoform b.
      Source sequence(s)
      AC239868
      Consensus CDS
      CCDS30846.1
      UniProtKB/Swiss-Prot
      Q5QNW6
      Related
      ENSP00000358164.1, ENST00000369167.2
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B
    2. NM_001161334.1NP_001154806.1  histone H2B type 2-F isoform b

      See identical proteins and their annotated locations for NP_001154806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (b)
      Source sequence(s)
      AK296916, DA042901
      Consensus CDS
      CCDS53359.1
      UniProtKB/Swiss-Prot
      Q5QNW6
      Related
      ENSP00000445831.1, ENST00000545683.1
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      149782689..149812373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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