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    FMO4 flavin containing dimethylaniline monoxygenase 4 [ Homo sapiens (human) ]

    Gene ID: 2329, updated on 21-Dec-2019

    Summary

    Official Symbol
    FMO4provided by HGNC
    Official Full Name
    flavin containing dimethylaniline monoxygenase 4provided by HGNC
    Primary source
    HGNC:HGNC:3772
    See related
    Ensembl:ENSG00000076258 MIM:136131
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FMO2
    Summary
    Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in kidney (RPKM 11.6), liver (RPKM 9.8) and 23 other tissues See more
    Orthologs

    Genomic context

    See FMO4 in Genome Data Viewer
    Location:
    1q24.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (171314131..171342084)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (171283318..171311223)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371611 Neighboring gene flavin containing dimethylaniline monoxygenase 2 Neighboring gene flavin containing dimethylaniline monoxygenase 1 Neighboring gene high mobility group box 1 pseudogene 11 Neighboring gene DNA topoisomerase I pseudogene 1 Neighboring gene signal recognition particle 14 pseudogene 4 Neighboring gene GM2 ganglioside activator pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N,N-dimethylaniline monooxygenase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    drug catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 4
    Names
    FMO 4
    dimethylaniline oxidase 4
    flavin containing monooxygenase 4
    hepatic flavin-containing monooxygenase 4
    NP_002013.1
    XP_005245102.1
    XP_005245103.1
    XP_005245105.1
    XP_006711306.1
    XP_011507649.1
    XP_011507650.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002022.3NP_002013.1  dimethylaniline monooxygenase [N-oxide-forming] 4

      See identical proteins and their annotated locations for NP_002013.1

      Status: REVIEWED

      Source sequence(s)
      BC002780, BX495448
      Consensus CDS
      CCDS1295.1
      UniProtKB/Swiss-Prot
      P31512
      Related
      ENSP00000356723.3, ENST00000367749.4
      Conserved Domains (3) summary
      pfam00743
      Location:2532
      FMO-like; Flavin-binding monooxygenase-like
      pfam13450
      Location:741
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:89220
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      171314131..171342084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711243.3XP_006711306.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X5

      Conserved Domains (2) summary
      pfam00743
      Location:2355
      FMO-like; Flavin-binding monooxygenase-like
      pfam13450
      Location:741
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    2. XM_005245048.3XP_005245105.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X6

      Conserved Domains (2) summary
      pfam00743
      Location:2300
      FMO-like; Flavin-binding monooxygenase-like
      pfam13450
      Location:741
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    3. XM_005245046.3XP_005245103.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X2

      Conserved Domains (3) summary
      pfam00743
      Location:2469
      FMO-like; Flavin-binding monooxygenase-like
      pfam13450
      Location:741
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:77157
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_011509347.2XP_011507649.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X3

      Conserved Domains (3) summary
      pfam00743
      Location:2436
      FMO-like; Flavin-binding monooxygenase-like
      pfam13450
      Location:741
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:89220
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. XM_005245045.3XP_005245102.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X1

      Conserved Domains (2) summary
      pfam00743
      Location:1482
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:39170
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. XM_011509348.2XP_011507650.1  dimethylaniline monooxygenase [N-oxide-forming] 4 isoform X4

      Conserved Domains (1) summary
      pfam00743
      Location:1389
      FMO-like; Flavin-binding monooxygenase-like

    RNA

    1. XR_002959842.1 RNA Sequence

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