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    dph6 diphthamine biosynthesis 6 [ Danio rerio (zebrafish) ]

    Gene ID: 503603, updated on 2-Nov-2024

    Summary

    Official Symbol
    dph6provided by ZNC
    Official Full Name
    diphthamine biosynthesis 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050227-15
    See related
    Ensembl:ENSDARG00000042839 AllianceGenome:ZFIN:ZDB-GENE-050227-15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    atpbd4; wu:fc57a01; zgc:110758; si:ch1073-258j7.1
    Summary
    Predicted to enable ATP binding activity and diphthine-ammonia ligase activity. Predicted to be involved in protein histidyl modification to diphthamide. Is expressed in female organism. Orthologous to human DPH6 (diphthamine biosynthesis 6). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
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    Genomic context

    See dph6 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (53156642..53187119)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (53068663..53143560)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438055 Neighboring gene Meis homeobox 2a Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene NIMA related kinase 9 Neighboring gene vasohibin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables diphthine-ammonia ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    diphthine--ammonia ligase
    Names
    ATP binding domain 4
    ATP-binding domain-containing protein 4
    DPH6 homolog
    diphthamide synthase
    diphthamide synthetase
    protein DPH6 homolog
    NP_001013308.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013290.2NP_001013308.2  diphthine--ammonia ligase

      See identical proteins and their annotated locations for NP_001013308.2

      Status: PROVISIONAL

      Source sequence(s)
      BC133118
      UniProtKB/Swiss-Prot
      A2RV01, Q5EAS1
      Related
      ENSDARP00000129691.1, ENSDART00000156774.2
      Conserved Domains (1) summary
      cd01994
      Location:2214
      Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      53156642..53187119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)