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    Rv0948c chorismate mutase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885485, updated on 6-Oct-2023

    Summary

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    Gene symbol
    Rv0948c
    Gene description
    chorismate mutase
    Locus tag
    Rv0948c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (1057646..1057963, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphate isomerase Neighboring gene pseudo Neighboring gene ATP-dependent DNA helicase UvrD Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H(37)R(v) and the secreted chorismate mutase (y2828) from Yersinia pestis. Kim SK, et al. FEBS J, 2008 Oct. PMID 18727669
    2. Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway. Munack S, et al. J Mol Biol, 2016 Mar 27. PMID 26776476
    3. A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis. Okvist M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Oct 1. PMID 19851019, Free PMC Article
    4. Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner. Sasso S, et al. EMBO J, 2009 Jul 22. PMID 19556970, Free PMC Article
    5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors show how DAHP synthase serves as an allosteric platform for feedback regulation of both enzymes, DAHP synthase and chorismate mutase.
      Title: Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway.
    2. MtCM was crystallized alone and in complex with MtDS. The crystals diffracted to 1.6 and 2.2 A resolution, respectively.
      Title: A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis.
    3. The intracellular chorismate mutase of Mycobacterium tuberculosis (MtCM; Rv0948c) has poor activity and lacks prominent active-site residues. However, its catalytic efficiency increases >100-fold on addition of DAHP synthase (MtDS; Rv2178c).
      Title: Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.
    4. The 2.0A X-ray structure shows that 90-MtCM is an all alpha-helical homodimer with the topology of Escherichia coli CM, and that both protomers contribute to each catalytic site.
      Title: A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H(37)R(v) and the secreted chorismate mutase (y2828) from Yersinia pestis.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    chorismate mutase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1057646..1057963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215463.1 chorismate mutase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215463.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4M559
      Conserved Domains (1) summary
      PRK07857
      Location:1 → 93
      PRK07857; chorismate mutase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WIC1.1

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