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    gag Pr65 [ Moloney murine leukemia virus ]

    Gene ID: 1491870, updated on 18-Aug-2023

    Summary

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    Gene symbol
    gag
    Gene description
    Pr65
    Locus tag
    MLVgp8
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Moloney murine leukemia virus
    Lineage
    Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus; Murine leukemia virus
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    Genomic context

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    Sequence:
    NC_001501.1 (357..1973)

    NC_001501.1Genomic Context describing neighboring genes Neighboring gene gPr80 Neighboring gene Pr180 Neighboring gene Neighboring gene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001501.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation Requirement of Murine Leukemia Virus p12. Brzezinski JD, et al. J Virol, 2016 Dec 15. PMID 27707931, Free PMC Article
    2. Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12. Brzezinski JD, et al. J Virol, 2016 Dec 15. PMID 27707926, Free PMC Article
    3. The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex. Usami Y, et al. J Virol, 2014 Mar. PMID 24403584, Free PMC Article
    4. The retrovirus MA and PreTM proteins follow immature MLV cores. Andersen KB. Virus Res, 2013 Aug. PMID 23643491
    5. A guanosine-centric mechanism for RNA chaperone function. Grohman JK, et al. Science, 2013 Apr 12. PMID 23470731, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation requirement of murine leukemia virus p12 virus p12 protein necessary for the host chromatin binding was elucidated.
      Title: Phosphorylation Requirement of Murine Leukemia Virus p12.
    2. The structure of the minimal sequence of the murine leukemia virus p12 protein necessary for the host chromatin binding was elucidated.
      Title: Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12.
    3. The N-terminal intracellular domain of the glycoGag is responsible for its effect on HIV-1 infectivity.
      Title: The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex.
    4. Authors found that mature Gag proteins MA and TM were bound to the immature core consisting of the Gag polyprotein (PrGag) and viral RNA (vRNA).
      Title: The retrovirus MA and PreTM proteins follow immature MLV cores.
    5. in presence of nucleocapsid (NC) chaperone, RNA dimerization occurred rapidly through a single structural intermediate; NC interacted primarily with guanosine residues; results show RNA chaperones can simplify RNA folding landscapes by weakening intramolecular interactions involving guanosine
      Title: A guanosine-centric mechanism for RNA chaperone function.
    6. selective packaging of dimeric RNA is explained by the nucleic acid binding domain derived from Gag binding within the virus to the sequence UCUG-UR-UCUG
      Title: Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome.
    7. Basal budding and replication of the murine leukemia virus are independent of the gag L domains
      Title: Basal budding and replication of the murine leukemia virus are independent of the gag L domains.
    8. Abl protein contribute to proper localization by playing a dominant role in trafficking of the v-Abl molecule
      Title: Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV.
    9. results suggest a cooperative effect of p12 and capsid during the early events of MLV replication
      Title: Cooperative effect of gag proteins p12 and capsid during early events of murine leukemia virus replication.
    10. interaction of Gag with Tsg101 and Alix favors budding from the plasma membrane and relieves a requirement for ubiquitination by Nedd4
      Title: Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    Pr65
    Names
    p15 MA
    pp12
    p30 CA
    p10 NC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001501.1 Reference assembly

      Range
      357..1973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_057934.1 Pr65 [Moloney murine leukemia virus]

      See identical proteins and their annotated locations for NP_057934.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03332, Q9WJP4
      UniProtKB/TrEMBL
      A0A126QCH7
      Conserved Domains (4) summary
      smart00343
      Location:503 → 519
      ZnF_C2HC; zinc finger
      pfam01140
      Location:2 → 131
      Gag_MA; Matrix protein (MA), p15
      pfam01141
      Location:132 → 215
      Gag_p12; Gag polyprotein, inner coat protein p12
      pfam02093
      Location:226 → 433
      Gag_p30; Gag P30 core shell protein

    2. NP_955583.1 p15 MA

      Conserved Domains (1) summary
      pfam01140
      Location:1 → 130
      Gag_MA; Matrix protein (MA), p15

    3. NP_955584.1 pp12

      Conserved Domains (1) summary
      pfam01141
      Location:1 → 84
      Gag_p12; Gag polyprotein, inner coat protein p12

    4. NP_955585.1 p30 CA

      UniProtKB/TrEMBL
      Q6JWR0
      Conserved Domains (1) summary
      pfam02093
      Location:11 → 218
      Gag_p30; Gag P30 core shell protein

    5. NP_955586.1 p10 NC

      UniProtKB/TrEMBL
      Q85655
      Conserved Domains (2) summary
      PTZ00368
      Location:15 → 50
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
      smart00343
      Location:25 → 41
      ZnF_C2HC; zinc finger
    Nucleotide Protein
    Heading Accession and Version

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