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    BCL6B BCL6B transcription repressor [ Homo sapiens (human) ]

    Gene ID: 255877, updated on 27-Nov-2024

    Summary

    Official Symbol
    BCL6Bprovided by HGNC
    Official Full Name
    BCL6B transcription repressorprovided by HGNC
    Primary source
    HGNC:HGNC:1002
    See related
    Ensembl:ENSG00000161940 MIM:608992; AllianceGenome:HGNC:1002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAZF; ZNF62; ZBTB28
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in fat (RPKM 17.2), lung (RPKM 14.1) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See BCL6B in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7023050..7029644)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6923650..6930294)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6926369..6932963)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mir-497-195 cluster host gene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47316 Neighboring gene microRNA 195 Neighboring gene microRNA 497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6938773-6939273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11596 Neighboring gene solute carrier family 16 member 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8083 Neighboring gene uncharacterized LOC124903909 Neighboring gene solute carrier family 16 member 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8085

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type 2 immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    B-cell CLL/lymphoma 6 member B protein
    Names
    B cell CLL/lymphoma 6B
    B-cell CLL/lymphoma 6, member B (zinc finger protein)
    bcl6-associated zinc finger protein
    zinc finger protein 62

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181844.4NP_862827.2  B-cell CLL/lymphoma 6 member B protein

      Status: VALIDATED

      Source sequence(s)
      AB076580, AC040977, AK122893, BC059404
      Consensus CDS
      CCDS42248.1
      UniProtKB/Swiss-Prot
      Q6PCB4, Q8N143
      Related
      ENSP00000293805.5, ENST00000293805.10
      Conserved Domains (5) summary
      COG5048
      Location:354411
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:330350
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:412434
      zf-C2H2; Zinc finger, C2H2 type
      cl38908
      Location:19132
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam13465
      Location:370395
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7023050..7029644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      6923650..6930294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)