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    GTF2A2 general transcription factor IIA subunit 2 [ Homo sapiens (human) ]

    Gene ID: 2958, updated on 21-Dec-2019

    Summary

    Official Symbol
    GTF2A2provided by HGNC
    Official Full Name
    general transcription factor IIA subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:4647
    See related
    Ensembl:ENSG00000140307 MIM:600519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TF2A2; TFIIA; T18745; TFIIAS; HsT18745; TFIIA-12; TFIIA-gamma
    Summary
    Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 46.4), colon (RPKM 13.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See GTF2A2 in Genome Data Viewer
    Location:
    15q22.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (59638062..59657515, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59930261..59949737, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 396 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene BCL2 interacting protein 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1 Neighboring gene RPS3A pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    transcription factor TFIIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIIA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription initiation factor IIA subunit 2
    Names
    TFIIA gamma subunit
    TFIIA p12 subunit
    general transcription factor IIA 2
    general transcription factor IIA, 2, 12kDa
    transcription initiation factor IIA gamma chain

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320929.2NP_001307858.1  transcription initiation factor IIA subunit 2

      Status: VALIDATED

      Source sequence(s)
      AC092755, BX099306, HY002503, HY036972
      Consensus CDS
      CCDS10173.1
      UniProtKB/Swiss-Prot
      P52657
      UniProtKB/TrEMBL
      A0A024R5Z5
      Related
      ENSP00000379373.1, ENST00000396061.5
      Conserved Domains (1) summary
      cl03508
      Location:3103
      TFIIA_gamma_N; Gamma subunit of transcription initiation factor IIA, N-terminal helical domain
    2. NM_001320930.2NP_001307859.1  transcription initiation factor IIA subunit 2

      Status: VALIDATED

      Source sequence(s)
      AC092755, BX099306, CB156109
      Consensus CDS
      CCDS10173.1
      UniProtKB/Swiss-Prot
      P52657
      UniProtKB/TrEMBL
      A0A024R5Z5
      Related
      ENSP00000379375.1, ENST00000396063.5
      Conserved Domains (1) summary
      cl03508
      Location:3103
      TFIIA_gamma_N; Gamma subunit of transcription initiation factor IIA, N-terminal helical domain
    3. NM_004492.3NP_004483.1  transcription initiation factor IIA subunit 2

      See identical proteins and their annotated locations for NP_004483.1

      Status: VALIDATED

      Source sequence(s)
      AK312015, BC000287, CV572751, DB531003
      Consensus CDS
      CCDS10173.1
      UniProtKB/Swiss-Prot
      P52657
      UniProtKB/TrEMBL
      A0A024R5Z5, B2R506
      Related
      ENSP00000379372.2, ENST00000396060.7
      Conserved Domains (1) summary
      cl03508
      Location:3103
      TFIIA_gamma_N; Gamma subunit of transcription initiation factor IIA, N-terminal helical domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      59638062..59657515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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