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    CDC5L cell division cycle 5 like [ Homo sapiens (human) ]

    Gene ID: 988, updated on 21-Dec-2019

    Summary

    Official Symbol
    CDC5Lprovided by HGNC
    Official Full Name
    cell division cycle 5 likeprovided by HGNC
    Primary source
    HGNC:HGNC:1743
    See related
    Ensembl:ENSG00000096401 MIM:602868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1
    Summary
    The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 9.6), bone marrow (RPKM 8.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See CDC5L in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (44387706..44450425)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44355251..44418161)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene alanyl-tRNA synthetase 2, mitochondrial Neighboring gene spermatogenesis associated serine rich 1 Neighboring gene microRNA 4642 Neighboring gene CRISPRi-validated cis-regulatory element chr6.3216 Neighboring gene uncharacterized LOC105375074

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
    NHGRI GWA Catalog
    Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.
    NHGRI GWA Catalog
    Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify CDC5 cell division cycle 5-like (CDC5L), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify CDC5 cell division cycle 5-like (CDC5L), hiv-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify CDC5 cell division cycle 5-like (CDC5L), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify CDC5 cell division cycle 5-like (CDC5L), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, CDC5 cell division cycle 5-like (CDC5L), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CDC5L is increased by RRE PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human CDC5 cell division cycle 5-like (CDC5L) at amino acid residues 231-232 and 495-496 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0432

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to fibroblast growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-2 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to prolactin IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to wortmannin IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction involved in DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with DNA replication factor A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Prp19 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    U2-type catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cell division cycle 5-like protein
    Names
    CDC5 cell division cycle 5-like
    Cdc5-related protein
    dJ319D22.1 (CDC5-like protein)
    pombe cdc5-related protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253.4NP_001244.1  cell division cycle 5-like protein

      See identical proteins and their annotated locations for NP_001244.1

      Status: REVIEWED

      Source sequence(s)
      AL133262, BC001568, DC422730
      Consensus CDS
      CCDS4912.1
      UniProtKB/Swiss-Prot
      Q99459
      Related
      ENSP00000360532.3, ENST00000371477.4
      Conserved Domains (3) summary
      COG1196
      Location:626802
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5147
      Location:6303
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam11831
      Location:404655
      Myb_Cef; pre-mRNA splicing factor component

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      44387706..44450425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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