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    MED6 mediator complex subunit 6 [ Homo sapiens (human) ]

    Gene ID: 10001, updated on 5-Nov-2017
    Official Symbol
    MED6provided by HGNC
    Official Full Name
    mediator complex subunit 6provided by HGNC
    Primary source
    HGNC:HGNC:19970
    See related
    Ensembl:ENSG00000133997 MIM:602984; Vega:OTTHUMG00000171252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARC33; NY-REN-28
    Orthologs
    Location:
    14q24.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (70583221..70600690, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (71050306..71067401, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370556 Neighboring gene ADAM metallopeptidase domain 20 Neighboring gene ADAM metallopeptidase domain 20 pseudogene Neighboring gene double homeobox A pseudogene 12 Neighboring gene keratin 18 pseudogene 7 Neighboring gene uncharacterized LOC101928075 Neighboring gene RNA, 7SL, cytoplasmic 77, pseudogene Neighboring gene tetratricopeptide repeat domain 9

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Replication interactions

    Interaction Pubs
    Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
    Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
    Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Knockdown of MED6 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed
    tat The interaction of HIV-1 Tat with MED21 hypothetically induces the binding of Tat to MED6 PubMed

    Go to the HIV-1, Human Interaction Database

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
      PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mediator complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    mediator of RNA polymerase II transcription subunit 6
    Names
    CTD-2540L5.5
    activator-recruited cofactor 33 kDa component
    renal carcinoma antigen NY-REN-28

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284209.1NP_001271138.1  mediator of RNA polymerase II transcription subunit 6 isoform 1

      See identical proteins and their annotated locations for NP_001271138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK300460, BM999935, DA869309, HY064772
      Consensus CDS
      CCDS61484.1
      UniProtKB/Swiss-Prot
      O75586
      Related
      ENSP00000413343.2, OTTHUMP00000245584, ENST00000430055.6, OTTHUMT00000412561
      Conserved Domains (1) summary
      pfam04934
      Location:13146
      Med6; MED6 mediator sub complex component
    2. NM_001284210.1NP_001271139.1  mediator of RNA polymerase II transcription subunit 6 isoform 3

      See identical proteins and their annotated locations for NP_001271139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK300460, AK304361, BM999935, DA869309, HY064772
      Consensus CDS
      CCDS61483.1
      UniProtKB/Swiss-Prot
      O75586
      Related
      ENSP00000394502.2, OTTHUMP00000245585, ENST00000440435.2, OTTHUMT00000412562
      Conserved Domains (1) summary
      pfam04934
      Location:13139
      Med6; MED6 mediator sub complex component
    3. NM_001284211.1NP_001271140.1  mediator of RNA polymerase II transcription subunit 6 isoform 4

      See identical proteins and their annotated locations for NP_001271140.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and differs in the 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (4) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK300460, BM802752, BM999935, DA869309, HY064772
      Consensus CDS
      CCDS73649.1
      UniProtKB/Swiss-Prot
      O75586
      UniProtKB/TrEMBL
      A0A087WYL7
      Related
      ENSP00000481920.1, ENST00000615788.4
      Conserved Domains (1) summary
      pfam04934
      Location:13139
      Med6; MED6 mediator sub complex component
    4. NM_005466.3NP_005457.2  mediator of RNA polymerase II transcription subunit 6 isoform 2

      See identical proteins and their annotated locations for NP_005457.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL357153, BC004106, BM999935, DA869309, HY064772
      Consensus CDS
      CCDS9805.1
      UniProtKB/Swiss-Prot
      O75586
      Related
      ENSP00000256379.5, OTTHUMP00000245583, ENST00000256379.9, OTTHUMT00000412560
      Conserved Domains (1) summary
      pfam04934
      Location:13139
      Med6; MED6 mediator sub complex component

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      70583221..70600690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      70988125..71005597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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