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    jag2a jagged canonical Notch ligand 2a [ Danio rerio (zebrafish) ]

    Gene ID: 566455, updated on 11-Apr-2024

    Summary

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    Official Symbol
    jag2aprovided by ZNC
    Official Full Name
    jagged canonical Notch ligand 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-130530-549
    See related
    Ensembl:ENSDARG00000014246 AllianceGenome:ZFIN:ZDB-GENE-130530-549
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable Notch binding activity and calcium ion binding activity. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in ectoderm; ionocyte progenitor cell; pronephros; and yolk syncytial layer. Orthologous to human JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 13
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (33487865..33556611)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (33378338..33447066)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene finTRIM family, member 80 Neighboring gene finTRIM family, member 81 Neighboring gene cofilin 1 (non-muscle), like Neighboring gene ribosome binding protein 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos. Lu YF, et al. PLoS Genet, 2021 Dec. PMID 34962934, Free PMC Article
    2. Zebrafish as an animal model to study ion homeostasis. Hwang PP, et al. Pflugers Arch, 2013 Sep. PMID 23568368, Free PMC Article
    3. Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo. Jänicke M, et al. Dev Biol, 2007 Jul 15. PMID 17555741
    4. Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish. Wada Y, et al. Development, 2022 Apr 1. PMID 35388409
    5. Notch signaling enhances bone regeneration in the zebrafish mandible. Kraus JM, et al. Development, 2022 Mar 1. PMID 35178545, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos.
      Title: Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Notch binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein jagged-2-like
    Names
    jagged 2a
    zmp:0000000546

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      33487865..33556611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689725.8 → XP_694817.5  protein jagged-2-like isoform X1

      UniProtKB/TrEMBL
      A0A8N7TDN4
      Related
      ENSDARP00000026847.10, ENSDART00000025007.10
      Conserved Domains (4) summary
      smart00215
      Location:864 → 936
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:373 → 409
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01414
      Location:167 → 228
      DSL; Delta serrate ligand
      pfam07657
      Location:26 → 97
      MNNL; N terminus of Notch ligand

    2. XM_005156965.4 → XP_005157022.1  protein jagged-2-like isoform X2

      UniProtKB/TrEMBL
      A0A8M2B354
      Conserved Domains (4) summary
      smart00215
      Location:826 → 898
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:373 → 409
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01414
      Location:167 → 228
      DSL; Delta serrate ligand
      pfam07657
      Location:26 → 97
      MNNL; N terminus of Notch ligand
    Nucleotide Protein Strain
    Heading Accession and Version

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