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    gipr gastric inhibitory polypeptide receptor [ Danio rerio (zebrafish) ]

    Gene ID: 101885360, updated on 11-Apr-2024

    Summary

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    Official Symbol
    giprprovided by ZNC
    Official Full Name
    gastric inhibitory polypeptide receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050516-4
    See related
    Ensembl:ENSDARG00000025478 AllianceGenome:ZFIN:ZDB-GENE-050516-4
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-188j1.2
    Summary
    Predicted to enable G protein-coupled peptide receptor activity; gastric inhibitory peptide receptor activity; and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (28940188..28974062)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (29007262..29041186)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 4 Neighboring gene EMAP like 2 Neighboring gene CAP-GLY domain containing linker protein 3 Neighboring gene dharma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of new hormone function: loss and gain of a receptor. Irwin DM, et al. J Hered, 2005 May-Jun. PMID 15653559
    2. A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates. Park CR, et al. PLoS One, 2013. PMID 23776481, Free PMC Article
    3. Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Cruz SA, et al. Comp Biochem Physiol A Mol Integr Physiol, 2010 Jun. PMID 20138234
    4. Functional Pairing of Class B1 Ligand-GPCR in Cephalochordate Provides Evidence of the Origin of PTH and PACAP/Glucagon Receptor Family. On JS, et al. Mol Biol Evol, 2015 Aug. PMID 25841489, Free PMC Article
    5. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gastric inhibitory peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gastric inhibitory peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gastric inhibitory polypeptide receptor-like
    Names
    zgcg-r1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      28940188..28974062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291758.3 → XP_009290033.1  gastric inhibitory polypeptide receptor-like isoform X2

      UniProtKB/TrEMBL
      A0A8M3B170, X1WDQ9
      Related
      ENSDARP00000128358.1, ENSDART00000154085.3
      Conserved Domains (2) summary
      pfam00002
      Location:124 → 377
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52 → 106
      HRM; Hormone receptor domain

    2. XM_021466442.1 → XP_021322117.1  gastric inhibitory polypeptide receptor-like isoform X3

      UniProtKB/TrEMBL
      A0A8M9NYP1
      Conserved Domains (3) summary
      pfam02793
      Location:52 → 121
      HRM; Hormone receptor domain
      cd14964
      Location:138 → 162
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:135 → 270
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_005157739.4 → XP_005157796.1  gastric inhibitory polypeptide receptor-like isoform X1

      See identical proteins and their annotated locations for XP_005157796.1

      UniProtKB/TrEMBL
      A0A8M2B409, E7FCX8
      Related
      ENSDARP00000038331.7, ENSDART00000029459.8
      Conserved Domains (2) summary
      pfam00002
      Location:139 → 392
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52 → 121
      HRM; Hormone receptor domain
    Nucleotide Protein Strain
    Heading Accession and Version

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