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    eIF3l eukaryotic translation initiation factor 3 subunit l [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39386, updated on 4-Apr-2024

    Summary

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    Official Symbol
    eIF3lprovided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 3 subunit lprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036258
    Locus tag
    Dmel_CG5642
    See related
    AllianceGenome:FB:FBgn0036258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5642; Dmel\CG5642
    Summary
    Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol. Is expressed in adult head; adult heart; and organism. Orthologous to human EIF3L (eukaryotic translation initiation factor 3 subunit L). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    68F6-68F6; 3-38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12143446..12146097, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12136546..12139197, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) SGDH subunit Neighboring gene Autophagy-related 12 Neighboring gene Rho GTPase activating protein at 68F Neighboring gene Neurexin IV Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila. Yi P, et al. Dev Cell, 2008 Nov. PMID 19000835, Free PMC Article
    2. RACK1 controls IRES-mediated translation of viruses. Majzoub K, et al. Cell, 2014 Nov 20. PMID 25416947, Free PMC Article
    3. Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing. Foley LE, et al. Elife, 2019 Nov 8. PMID 31702555, Free PMC Article
    4. TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals. Jin H, et al. Sci Adv, 2020 Aug. PMID 32851185, Free PMC Article
    5. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit l
    Names
    CG5642-PA
    eIF3l-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12143446..12146097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140296.3 → NP_648553.1  eukaryotic translation initiation factor 3 subunit l [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648553.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTU4
      Related
      FBpp0075754
      Conserved Domains (1) summary
      pfam10255
      Location:122 → 527
      Paf67; RNA polymerase I-associated factor PAF67
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTU4.1 Q9VTU4

    Gene LinkOut

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