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    FCGR3A Fc gamma receptor IIIa [ Homo sapiens (human) ]

    Gene ID: 2214, updated on 3-Apr-2024

    Summary

    Official Symbol
    FCGR3Aprovided by HGNC
    Official Full Name
    Fc gamma receptor IIIaprovided by HGNC
    Primary source
    HGNC:HGNC:3619
    See related
    Ensembl:ENSG00000203747 MIM:146740; AllianceGenome:HGNC:3619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; CD16-II; FCGRIII; FCRIIIA; FcGRIIIA
    Summary
    This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
    Expression
    Biased expression in spleen (RPKM 154.1), lung (RPKM 70.6) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FCGR3A in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161541759..161550737, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160804385..160813363, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161511549..161520527, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1482 Neighboring gene ribosomal protein S23 pseudogene 10 Neighboring gene tRNA-Asn (anticodon GTT) 1-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161518401-161518900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161547932-161548874 Neighboring gene Fc gamma receptor IIc (gene/pseudogene) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161559016-161559516 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:161562499-161562705 Neighboring gene heat shock protein family A (Hsp70) member 7 (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 is vertically transmitted more readily by mothers who are heterozygous for high-affinity and low-affinity FCGR3A PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57 PubMed
    env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
    Nef nef Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Nef may antagonize restriction activity of FCGR3A against production of infectious wild-type HIV-1 PubMed
    Tat tat HIV-1 Tat upregulates the expression of CCR2, CD16, and TLR4 in monocyte-derived macrophages PubMed
    tat HIV-1 Tat inhibits the rise in intracellular free calcium concentration in Natural Killer (NK) cells upon cross-linking of the adhesion molecule CD11a and the activation molecule CD16, indicating Tat is involved in the impairment of NK cell function PubMed
    Vpr vpr Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of FCGR3A against production of infectious wild-type HIV-1 PubMed
    Vpu vpu The ability of HIV-1 Vpu to antagonize tetherin is important for the antibody opsonization of HIV-infected cells, which in turn increases FCGRIII (CD16) signaling PubMed
    vpu Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of FCGR3A against production of infectious wild-type HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgG binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables IgG receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables immune receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables low-affinity IgG receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor III-A
    Names
    CD16a antigen
    Fc fragment of IgG receptor IIIa
    Fc fragment of IgG, low affinity III, receptor for (CD16)
    Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
    Fc gamma receptor III-A
    Fc-gamma RIII-alpha
    Fc-gamma receptor III-2 (CD 16)
    Fc-gamma receptor IIIb (CD16)
    FcgammaRIIIA
    IgG Fc receptor III-A
    igG Fc receptor III-2
    immunoglobulin G Fc receptor III
    low affinity immunoglobulin gamma Fc region receptor III-A/III-B recombinant
    low affinity immunoglobulin gamma Fc region receptor III-B
    low affinity immunoglobulin gamma receptor III-a Fc fragment
    neutrophil-specific antigen NA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009066.1 RefSeqGene

      Range
      5001..13865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_60

    mRNA and Protein(s)

    1. NM_000569.8NP_000560.7  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) retains an intron in its 5' UTR and 5' coding region compared to variant 3. Variants 1, 3, 4 and 6 encode the same isoform (c).
      Source sequence(s)
      AK302126, BC033678
      Consensus CDS
      CCDS44266.1
      UniProtKB/Swiss-Prot
      A2N6W9, P08637, Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0
      UniProtKB/TrEMBL
      A0A8V8TPL1
      Related
      ENSP00000392047.2, ENST00000443193.6
      Conserved Domains (2) summary
      cd05752
      Location:26104
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:108190
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    2. NM_001127592.2NP_001121064.2  low affinity immunoglobulin gamma Fc region receptor III-A isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) retains an intron in its 5' UTR and 5' coding region, and uses an alternate in-frame splice site in its 5' coding region compared to variant 3. The encoded isoform (2) is longer than isoform c. This isoform (b) lacks a predicted signal peptide compared to isoform c.
      Source sequence(s)
      AK302126, BC036723, DA944383, M24853
      UniProtKB/TrEMBL
      A0A1W2PQB1
    3. NM_001127593.1NP_001121065.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

      See identical proteins and their annotated locations for NP_001121065.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform c. Variants 1, 3, 4 and 6 encode the same isoform (c).
      Source sequence(s)
      AL590385, BC036723, DA957430, M24853
      Consensus CDS
      CCDS44266.1
      UniProtKB/Swiss-Prot
      A2N6W9, P08637, Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0
      UniProtKB/TrEMBL
      A0A8V8TPL1
      Related
      ENSP00000416607.1, ENST00000436743.7
      Conserved Domains (2) summary
      cd05752
      Location:26104
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:108190
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    4. NM_001127595.2NP_001121067.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

      See identical proteins and their annotated locations for NP_001121067.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4 and 6 encode the same isoform (c).
      Source sequence(s)
      BC036723, DA933259, DA957430, M24853
      Consensus CDS
      CCDS44266.1
      UniProtKB/Swiss-Prot
      A2N6W9, P08637, Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0
      UniProtKB/TrEMBL
      A0A8V8TPL1
      Related
      ENSP00000356944.3, ENST00000367967.8
      Conserved Domains (2) summary
      cd05752
      Location:26104
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:108190
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    5. NM_001127596.2NP_001121068.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform d precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 3. The encoded isoform (d) is shorter than isoform c.
      Source sequence(s)
      BC036723, DA674960, DA957430, M24853
      Consensus CDS
      CCDS91089.1
      UniProtKB/TrEMBL
      A0A8V8TPL1, H0Y755
      Related
      ENSP00000514361.1, ENST00000699400.1
      Conserved Domains (2) summary
      cd05752
      Location:25103
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:107189
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    6. NM_001329120.2NP_001316049.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4 and 6 encode the same isoform (c).
      Source sequence(s)
      AL590385, BC036723
      Consensus CDS
      CCDS44266.1
      UniProtKB/Swiss-Prot
      A2N6W9, P08637, Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0
      UniProtKB/TrEMBL
      A0A8V8TPL1
      Related
      ENSP00000514358.1, ENST00000699397.1
      Conserved Domains (2) summary
      cd05752
      Location:26104
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:108190
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    7. NM_001329122.1NP_001316051.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) retains an intron in its 5' UTR and 5' coding region, and lacks an alternate in-frame exon in its 3' coding region compared to variant 3. The encoded isoform is longer than isoform c. This isoform (e) lacks a predicted signal peptide compared to isoform c.
      Source sequence(s)
      AL590385, BC036723
    8. NM_001386450.1NP_001373379.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AL590385
      Consensus CDS
      CCDS91089.1
      UniProtKB/TrEMBL
      A0A8V8TPL1, H0Y755
      Conserved Domains (2) summary
      cd05752
      Location:25103
      Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
      cd05753
      Location:107189
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161541759..161550737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449444.1XP_047305400.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform X2

    2. XM_047449443.1XP_047305399.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      160804385..160813363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)