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    FCAR Fc alpha receptor [ Homo sapiens (human) ]

    Gene ID: 2204, updated on 11-Apr-2024

    Summary

    Official Symbol
    FCARprovided by HGNC
    Official Full Name
    Fc alpha receptorprovided by HGNC
    Primary source
    HGNC:HGNC:3608
    See related
    Ensembl:ENSG00000186431 MIM:147045; AllianceGenome:HGNC:3608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD89; FcalphaR; FcalphaRI; CTB-61M7.2
    Summary
    This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward bone marrow (RPKM 95.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FCAR in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54874235..54891420)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57968550..57985728)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55385691..55402786)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 Neighboring gene RNA, U6 small nuclear 222, pseudogene Neighboring gene MPRA-validated peak3560 silencer Neighboring gene Sharpr-MPRA regulatory region 15416 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55404005-55404755 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55404756-55405506 Neighboring gene natural cytotoxicity triggering receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55431695-55432196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55432197-55432696 Neighboring gene NLR family pyrin domain containing 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:55450505-55451214 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:55461990-55462680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:55463371-55464060 Neighboring gene NLR family pyrin domain containing 2 Neighboring gene ribosomal protein L36a pseudogene 50

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    immunoglobulin alpha Fc receptor
    Names
    Fc fragment of IgA receptor
    Fc fragment of IgA, receptor for

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002000.4NP_001991.1  immunoglobulin alpha Fc receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001991.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as a.1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC245128, AK290922, BC027953
      Consensus CDS
      CCDS12907.1
      UniProtKB/Swiss-Prot
      P24071, Q13603, Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0
      UniProtKB/TrEMBL
      A0A0G2JLU6
      Related
      ENSP00000347714.3, ENST00000355524.8
      Conserved Domains (2) summary
      cd05711
      Location:125215
      Ig2_LILR_KIR_like; Second immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, natural and similar domains
      cd05751
      Location:27120
      Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains
    2. NM_133269.4NP_579803.1  immunoglobulin alpha Fc receptor isoform b precursor

      See identical proteins and their annotated locations for NP_579803.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as a.2, delta66EC2, or U06) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC245128, AK290922, U43774
      Consensus CDS
      CCDS42622.1
      UniProtKB/TrEMBL
      A0A0G2JPZ4
      Related
      ENSP00000375605.3, ENST00000391725.7
      Conserved Domains (1) summary
      cl11960
      Location:125197
      Ig; Immunoglobulin domain
    3. NM_133271.4NP_579805.1  immunoglobulin alpha Fc receptor isoform c precursor

      See identical proteins and their annotated locations for NP_579805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as a.3, Rla2, deltaE2, or U08) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC245128, AK290922, S82919
      Consensus CDS
      CCDS12908.1
      UniProtKB/TrEMBL
      A0A0G2JPP7
      Related
      ENSP00000338257.4, ENST00000345937.8
      Conserved Domains (1) summary
      cl11960
      Location:27120
      Ig; Immunoglobulin domain
    4. NM_133272.4NP_579806.1  immunoglobulin alpha Fc receptor isoform d

      See identical proteins and their annotated locations for NP_579806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as deltaS2 or U11) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC245128, AK290922, D87855
      Consensus CDS
      CCDS12909.1
      UniProtKB/TrEMBL
      A0A0G2JNH4
      Related
      ENSP00000352218.4, ENST00000359272.8
      Conserved Domains (2) summary
      cd05711
      Location:113203
      Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
      cl11960
      Location:15108
      Ig; Immunoglobulin domain
    5. NM_133273.4NP_579807.1  immunoglobulin alpha Fc receptor isoform e

      See identical proteins and their annotated locations for NP_579807.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as U10) lacks alternate in-frame exons in the 5' and 3' coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AC245128, AK290922, BC027953, BX643574
      Consensus CDS
      CCDS42624.1
      UniProtKB/TrEMBL
      A0A0G2JPP7
      Related
      ENSP00000375606.3, ENST00000391726.7
      Conserved Domains (1) summary
      cl11960
      Location:15108
      Ig; Immunoglobulin domain
    6. NM_133274.4NP_579808.1  immunoglobulin alpha Fc receptor isoform f

      See identical proteins and their annotated locations for NP_579808.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as U09) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC245128, AK290922, D87857
      Consensus CDS
      CCDS42625.1
      UniProtKB/TrEMBL
      A0A0G2JP11
      Related
      ENSP00000375603.3, ENST00000391723.7
      Conserved Domains (1) summary
      cl11960
      Location:113180
      Ig; Immunoglobulin domain
    7. NM_133277.4NP_579811.1  immunoglobulin alpha Fc receptor isoform g

      See identical proteins and their annotated locations for NP_579811.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as deltaS2ECl or L10) lacks two in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.
      Source sequence(s)
      AC245128, AK290922, D87861
      Consensus CDS
      CCDS12910.1
      UniProtKB/Swiss-Prot
      P24071
      Related
      ENSP00000338058.4, ENST00000353758.8
      Conserved Domains (1) summary
      cd05711
      Location:16106
      Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    8. NM_133278.4NP_579812.1  immunoglobulin alpha Fc receptor isoform h

      See identical proteins and their annotated locations for NP_579812.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as deltaS266Ec2 or U13) lacks an in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
      Source sequence(s)
      AC245128, AK290922, X92559
      Consensus CDS
      CCDS42623.1
      UniProtKB/TrEMBL
      A0A0G2JM27
      Related
      ENSP00000375604.3, ENST00000391724.3
      Conserved Domains (1) summary
      cl11960
      Location:113185
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54874235..54891420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438406.1XP_047294362.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_011526625.4XP_011524927.1  immunoglobulin alpha Fc receptor isoform X1

      See identical proteins and their annotated locations for XP_011524927.1

      UniProtKB/TrEMBL
      A0A0G2JNH4
      Conserved Domains (2) summary
      cd05711
      Location:98188
      Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
      cl11960
      Location:293
      Ig; Immunoglobulin domain
    3. XM_047438407.1XP_047294363.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_017026474.2XP_016881963.1  immunoglobulin alpha Fc receptor isoform X1

      UniProtKB/TrEMBL
      A0A0G2JNH4
      Conserved Domains (2) summary
      cd05711
      Location:98188
      Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
      cl11960
      Location:293
      Ig; Immunoglobulin domain

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_016107304.1 Reference GRCh38.p14 PATCHES

      Range
      203308..220493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332039.1XP_054188014.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054332038.1XP_054188013.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054332040.1XP_054188015.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054332041.1XP_054188016.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_016107312.1 Reference GRCh38.p14 PATCHES

      Range
      20566..37751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332051.1XP_054188026.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054332050.1XP_054188025.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054332052.1XP_054188027.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      519503..536649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330151.1XP_054186126.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054330152.1XP_054186127.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054330154.1XP_054186129.1  immunoglobulin alpha Fc receptor isoform X2

      UniProtKB/TrEMBL
      A0A1P8A760
    4. XM_054330153.1XP_054186128.1  immunoglobulin alpha Fc receptor isoform X1

    5. XM_054330155.1XP_054186130.1  immunoglobulin alpha Fc receptor isoform X3

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      778610..795785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331498.1XP_054187473.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054331497.1XP_054187472.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054331499.1XP_054187474.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054331500.1XP_054187475.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      856805..873900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333635.1XP_054189610.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054333636.1XP_054189611.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054333638.1XP_054189613.1  immunoglobulin alpha Fc receptor isoform X4

      UniProtKB/TrEMBL
      A0A1P8A760
    4. XM_054333637.1XP_054189612.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_23

    Genomic

    1. NT_187671.1 Reference GRCh38.p14 ALT_REF_LOCI_23

      Range
      153182..170367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333459.1XP_054189434.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054333458.1XP_054189433.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054333460.1XP_054189435.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054333461.1XP_054189436.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_26

    Genomic

    1. NT_187674.1 Reference GRCh38.p14 ALT_REF_LOCI_26

      Range
      160255..177440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333465.1XP_054189440.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054333464.1XP_054189439.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054333466.1XP_054189441.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054333467.1XP_054189442.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_27

    Genomic

    1. NT_187675.1 Reference GRCh38.p14 ALT_REF_LOCI_27

      Range
      244474..261659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333471.1XP_054189446.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054333470.1XP_054189445.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054333472.1XP_054189447.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054333473.1XP_054189448.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_28

    Genomic

    1. NT_187676.1 Reference GRCh38.p14 ALT_REF_LOCI_28

      Range
      150185..167370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333479.1XP_054189454.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054333478.1XP_054189453.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054333480.1XP_054189455.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054333481.1XP_054189456.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_29

    Genomic

    1. NT_187677.1 Reference GRCh38.p14 ALT_REF_LOCI_29

      Range
      151602..168787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333485.1XP_054189460.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054333484.1XP_054189459.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054333486.1XP_054189461.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054333487.1XP_054189462.1  immunoglobulin alpha Fc receptor isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_30

    Genomic

    1. NT_187683.1 Reference GRCh38.p14 ALT_REF_LOCI_30

      Range
      148453..165638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333491.1XP_054189466.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054333490.1XP_054189465.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054333492.1XP_054189467.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054333493.1XP_054189468.1  immunoglobulin alpha Fc receptor isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57968550..57985728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320195.1XP_054176170.1  immunoglobulin alpha Fc receptor isoform X1

    2. XM_054320194.1XP_054176169.1  immunoglobulin alpha Fc receptor isoform X1

    3. XM_054320196.1XP_054176171.1  immunoglobulin alpha Fc receptor isoform X1

    4. XM_054320197.1XP_054176172.1  immunoglobulin alpha Fc receptor isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133279.2: Suppressed sequence

      Description
      NM_133279.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_133280.1: Suppressed sequence

      Description
      NM_133280.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.