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    AK5 adenylate kinase 5 [ Homo sapiens (human) ]

    Gene ID: 26289, updated on 2-May-2024

    Summary

    Official Symbol
    AK5provided by HGNC
    Official Full Name
    adenylate kinase 5provided by HGNC
    Primary source
    HGNC:HGNC:365
    See related
    Ensembl:ENSG00000154027 MIM:608009; AllianceGenome:HGNC:365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AK6
    Summary
    This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 40.3) and testis (RPKM 0.8) See more
    Orthologs
    NEW
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    Genomic context

    See AK5 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (77282019..77559966)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (77120194..77398823)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (77747704..78025651)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class K Neighboring gene alanyl-tRNA synthetase domain containing 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1214 Neighboring gene uncharacterized LOC105378808 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:77730892-77731409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1001 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:77777635-77778136 Neighboring gene Sharpr-MPRA regulatory region 3902 Neighboring gene uncharacterized LOC124904202 Neighboring gene RNA, U7 small nuclear 8 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:77962170-77963369 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:77980030-77980998 Neighboring gene Sharpr-MPRA regulatory region 12904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1215 Neighboring gene zinc finger ZZ-type containing 3 Neighboring gene RNA, 5S ribosomal pseudogene 20 Neighboring gene RNA, 7SL, cytoplasmic 370, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of adenylate kinase 5 (AK5) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33326

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nucleoside diphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dADP biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyrimidine ribonucleotide biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    adenylate kinase isoenzyme 5
    Names
    AK 5
    ATP-AMP transphosphorylase 5
    adenylate kinase 6
    NP_036225.2
    NP_777283.1
    XP_005270796.1
    XP_006710635.1
    XP_016856497.1
    XP_016856501.1
    XP_047273677.1
    XP_047273696.1
    XP_054191933.1
    XP_054191934.1
    XP_054191935.1
    XP_054191936.1
    XP_054191937.1
    XP_054191938.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012093.4NP_036225.2  adenylate kinase isoenzyme 5 isoform 2

      See identical proteins and their annotated locations for NP_036225.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate and longer first exon which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC093433, AC093575, AC095030, KF459522
      Consensus CDS
      CCDS676.1
      UniProtKB/Swiss-Prot
      Q9Y6K8
      Related
      ENSP00000341430.5, ENST00000344720.9
      Conserved Domains (2) summary
      TIGR01360
      Location:348535
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:352524
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    2. NM_174858.3NP_777283.1  adenylate kinase isoenzyme 5 isoform 1

      See identical proteins and their annotated locations for NP_777283.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript yet it encodes the longer protein (isoform 1).
      Source sequence(s)
      AF445193, AW665223, BC036666
      Consensus CDS
      CCDS675.1
      UniProtKB/Swiss-Prot
      Q5U622, Q6FH66, Q7Z4T5, Q86YS0, Q8N464, Q96EC9, Q9Y6K8
      Related
      ENSP00000346577.2, ENST00000354567.7
      Conserved Domains (2) summary
      TIGR01360
      Location:374561
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:378550
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      77282019..77559966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270739.6XP_005270796.1  adenylate kinase isoenzyme 5 isoform X1

      See identical proteins and their annotated locations for XP_005270796.1

      Conserved Domains (2) summary
      TIGR01360
      Location:350537
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:354526
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    2. XM_017001012.2XP_016856501.1  adenylate kinase isoenzyme 5 isoform X3

    3. XM_047417740.1XP_047273696.1  adenylate kinase isoenzyme 5 isoform X4

    4. XM_047417721.1XP_047273677.1  adenylate kinase isoenzyme 5 isoform X2

    5. XM_017001008.3XP_016856497.1  adenylate kinase isoenzyme 5 isoform X2

      UniProtKB/Swiss-Prot
      Q9Y6K8
      Conserved Domains (2) summary
      TIGR01360
      Location:348535
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:352524
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    6. XM_006710572.4XP_006710635.1  adenylate kinase isoenzyme 5 isoform X2

      See identical proteins and their annotated locations for XP_006710635.1

      UniProtKB/Swiss-Prot
      Q9Y6K8
      Conserved Domains (2) summary
      TIGR01360
      Location:348535
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:352524
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      77120194..77398823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335958.1XP_054191933.1  adenylate kinase isoenzyme 5 isoform X1

    2. XM_054335962.1XP_054191937.1  adenylate kinase isoenzyme 5 isoform X3

    3. XM_054335963.1XP_054191938.1  adenylate kinase isoenzyme 5 isoform X4

    4. XM_054335959.1XP_054191934.1  adenylate kinase isoenzyme 5 isoform X2

    5. XM_054335960.1XP_054191935.1  adenylate kinase isoenzyme 5 isoform X2

    6. XM_054335961.1XP_054191936.1  adenylate kinase isoenzyme 5 isoform X2