U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CD8A CD8 subunit alpha [ Homo sapiens (human) ]

    Gene ID: 925, updated on 11-Apr-2024

    Summary

    Official Symbol
    CD8Aprovided by HGNC
    Official Full Name
    CD8 subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:1706
    See related
    Ensembl:ENSG00000153563 MIM:186910; AllianceGenome:HGNC:1706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD8; p32; Leu2; IMD116; CD8alpha
    Summary
    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis.
    Expression
    Biased expression in spleen (RPKM 38.0), lymph node (RPKM 12.5) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CD8A in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (86784605..86808396, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (86786504..86810303, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87011728..87035519, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF103-CHMP3 readthrough Neighboring gene uncharacterized LOC124907853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86859935-86860458 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:86921806-86923005 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:86946607-86947140 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:86947334-86947492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86952106-86952606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:86952607-86953107 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16165 Neighboring gene CD8A intronic regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:87016737-87017571 Neighboring gene uncharacterized LOC105374846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11721 Neighboring gene MPRA-validated peak3783 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87066785-87067341 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87083199-87083700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:87083701-87084200 Neighboring gene CD8 subunit beta Neighboring gene ANAPC1 pseudogene 1 Neighboring gene RANBP2 like and GRIP domain containing 1 Neighboring gene WBP1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 cytoplasmic tail length determines interaction with CD8A; the presence of an amphipathic sequence in the HIV-1 Env cytoplasmic tail possibly modulates viral receptor specificity by inducing conformational changes in gp120 PubMed
    Nef nef HIV-1 Nef co-localizes with CD8-CD3 zeta on the HEK293 cell surface PubMed
    nef beta-COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation PubMed
    nef HIV-inoculated and HIV-1 Nef-treated human peripheral blood lymphocytes downregulate cell surface CD8, and this down-modulation could inhibit anti-HIV cytotoxicity associated with cytotoxic T-cell function PubMed
    Pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class I protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables MHC class I protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables coreceptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adaptive immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in antigen processing and presentation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytotoxic T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of T cell receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-cell surface glycoprotein CD8 alpha chain
    Names
    CD8 antigen, alpha polypeptide (p32)
    CD8a molecule
    Leu2 T-lymphocyte antigen
    OKT8 T-cell antigen
    T cell co-receptor
    T-cell antigen Leu2
    T-lymphocyte differentiation antigen T8/Leu-2
    T8 T-cell antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011608.2 RefSeqGene

      Range
      5001..28792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_44

    mRNA and Protein(s)

    1. NM_001145873.1NP_001139345.1  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001139345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 3 encode the longer, membrane associated isoform (1).
      Source sequence(s)
      AA668685, AK124156, BC025715, DA075688
      Consensus CDS
      CCDS1992.1
      UniProtKB/Swiss-Prot
      B4DT80, D6W5M8, P01732, Q13970, Q4ZG17
      UniProtKB/TrEMBL
      Q8TAW8, Q96QR6
      Related
      ENSP00000386559.2, ENST00000409511.6
      Conserved Domains (1) summary
      cd05720
      Location:24133
      IgV_CD8_alpha; Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain
    2. NM_001382698.1NP_001369627.1  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC064848, AC112696
      Consensus CDS
      CCDS1992.1
      UniProtKB/Swiss-Prot
      B4DT80, D6W5M8, P01732, Q13970, Q4ZG17
      UniProtKB/TrEMBL
      Q8TAW8, Q96QR6
      Conserved Domains (1) summary
      cd05720
      Location:24133
      IgV_CD8_alpha; Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain
    3. NM_001768.7NP_001759.3  T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001759.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer, membrane associated isoform (1). Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC064848, AK124156, BC025715
      Consensus CDS
      CCDS1992.1
      UniProtKB/Swiss-Prot
      B4DT80, D6W5M8, P01732, Q13970, Q4ZG17
      UniProtKB/TrEMBL
      Q8TAW8, Q96QR6
      Related
      ENSP00000283635.3, ENST00000283635.8
      Conserved Domains (1) summary
      cd05720
      Location:24133
      IgV_CD8_alpha; Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain
    4. NM_171827.4NP_741969.1  T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_741969.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) lacks an internal segment including the transmembrane domain compared to isoform 1, resulting in a secreted protein.
      Source sequence(s)
      AC064848
      Consensus CDS
      CCDS1993.1
      UniProtKB/TrEMBL
      Q8TAW8, Q96QR6
      Related
      ENSP00000321631.3, ENST00000352580.7
      Conserved Domains (2) summary
      cd05720
      Location:31133
      Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
      smart00410
      Location:28128
      IG_like; Immunoglobulin like

    RNA

    1. NR_027353.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' splice pattern, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC064848, AK300089, BC025715
    2. NR_168478.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC064848, AC112696
    3. NR_168479.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC064848, AC112696
    4. NR_168480.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC064848, AC112696
    5. NR_168481.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC064848, AC112696
      Related
      ENST00000699437.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      86784605..86808396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      86786504..86810303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)