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    MKI67 marker of proliferation Ki-67 [ Homo sapiens (human) ]

    Gene ID: 4288, updated on 5-May-2024

    Summary

    Official Symbol
    MKI67provided by HGNC
    Official Full Name
    marker of proliferation Ki-67provided by HGNC
    Primary source
    HGNC:HGNC:7107
    See related
    Ensembl:ENSG00000148773 MIM:176741; AllianceGenome:HGNC:7107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIA; MIB-; MIB-1; PPP1R105
    Summary
    Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett's esophagus; autoimmune disease of musculoskeletal system (multiple); endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and interstitial cystitis. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bone marrow (RPKM 18.5), lymph node (RPKM 8.4) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MKI67 in Genome Data Viewer
    Location:
    10q26.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (128096659..128126423, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (128995212..129024955, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (129894923..129924687, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129733337-129734076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129775634-129776134 Neighboring gene protein tyrosine phosphatase receptor type E Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129820967-129821467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129843223-129843724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129843725-129844224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4198 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:129860232-129861431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129861772-129862370 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:129867603-129867800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129876659-129877158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129876157-129876658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129889651-129890152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:129890153-129890652 Neighboring gene lncRNA antisense to PTPRE protein-coding gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2933 Neighboring gene NANOG hESC enhancer GRCh37_chr10:129963700-129964282 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:129970982-129972181 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:129999872-130000380 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:130000381-130000888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130007752-130008313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130109218-130109718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130109719-130110219 Neighboring gene uncharacterized LOC124902558 Neighboring gene long intergenic non-protein coding RNA 1163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130184885-130185386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130232943-130233444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130238232-130238732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130281351-130281852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130281853-130282352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130317555-130318446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130318447-130319337 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:130339525-130340200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130365840-130366340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:130366341-130366841 Neighboring gene VISTA enhancer hs737 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:130424650-130424847 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:130427109-130428308 Neighboring gene uncharacterized LOC105378554

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 increases MK167 (Ki67) expression and inversely correlates with PRDM1 (BLIMP1) expression in activated B cells from HIV-1-infected treatment naive individuals PubMed
    HIV-1 infection decreases MKI67 expression in hippocampal sections of brain autopsy tissue PubMed
    HIV-1 upregulates MKI67(Ki-67) in CD4+ and CD8+ T lymphocytes as observed in clinical samples collected from HIV-1 infected patients PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Podocyte-specific expression of HIV-1 Nef induces loss of synaptopodin and WT1, and expression of Ki-67 in podocytes, which is essential for the dedifferentiation and proliferation of podocytes in HIV-associated nephropathy PubMed
    Pr55(Gag) gag Cellular biotinylated marker of proliferation Ki-67 (MKI67) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag HIV-1 Gag co-localizes with Ki-67 in germinal center of HIV-1 infected patients PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proliferation marker protein Ki-67
    Names
    Molecular Immunology Borstel antibody 1
    antigen Ki67
    antigen identified by monoclonal antibody Ki-67
    proliferation-related Ki-67 antigen
    protein phosphatase 1, regulatory subunit 105

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047061.1 RefSeqGene

      Range
      4941..34705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145966.2NP_001139438.1  proliferation marker protein Ki-67 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL355529, AL390236, BU632619, BU855841, X65551
      Consensus CDS
      CCDS53588.1
      UniProtKB/Swiss-Prot
      P46013
      Related
      ENSP00000357642.3, ENST00000368653.7
      Conserved Domains (4) summary
      COG1716
      Location:11119
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:898
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:643752
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:143185
      PP1_bind; Protein phosphatase 1 binding
    2. NM_002417.5NP_002408.3  proliferation marker protein Ki-67 isoform 1

      See identical proteins and their annotated locations for NP_002408.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL355529, AL390236, BU632619, BU855841, X65550
      Consensus CDS
      CCDS7659.1
      UniProtKB/Swiss-Prot
      P46013, Q5VWH2
      Related
      ENSP00000357643.3, ENST00000368654.8
      Conserved Domains (4) summary
      COG1716
      Location:11119
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:898
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:10031112
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:503545
      PP1_bind; Protein phosphatase 1 binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      128096659..128126423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539818.3XP_011538120.1  proliferation marker protein Ki-67 isoform X2

      Conserved Domains (2) summary
      pfam08065
      Location:659768
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:159201
      PP1_bind; Protein phosphatase 1 binding
    2. XM_006717864.4XP_006717927.2  proliferation marker protein Ki-67 isoform X1

      Conserved Domains (1) summary
      pfam08065
      Location:229338
      K167R; K167R (NUC007) repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      128995212..129024955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365949.1XP_054221924.1  proliferation marker protein Ki-67 isoform X1