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    DUSP4 dual specificity phosphatase 4 [ Homo sapiens (human) ]

    Gene ID: 1846, updated on 10-Mar-2024

    Summary

    Official Symbol
    DUSP4provided by HGNC
    Official Full Name
    dual specificity phosphatase 4provided by HGNC
    Primary source
    HGNC:HGNC:3070
    See related
    Ensembl:ENSG00000120875 MIM:602747; AllianceGenome:HGNC:3070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TYP; HVH2; MKP2; MKP-2
    Summary
    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in stomach (RPKM 8.5), gall bladder (RPKM 5.0) and 19 other tissues See more
    Orthologs
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    Genomic context

    Location:
    8p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (29333064..29350684, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (29611341..29628961, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (29190581..29208201, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 13B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27183 Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19069 Neighboring gene uncharacterized LOC124901922 Neighboring gene Sharpr-MPRA regulatory region 4987 Neighboring gene uncharacterized LOC124901923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27184 Neighboring gene Sharpr-MPRA regulatory region 3532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:29207199-29207700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:29207701-29208200 Neighboring gene uncharacterized LOC124901924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27187 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:29212898-29213196 Neighboring gene NANOG hESC enhancer GRCh37_chr8:29215233-29215734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:29222945-29223445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27188 Neighboring gene uncharacterized LOC105379349

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Primary human Muller glia cells treated with HIV-1 clade B Tat, but not with clade C Tat, upregulate the expression of MKP-2 protein PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-tyrosine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dual specificity protein phosphatase 4
    Names
    MAP kinase phosphatase 2
    VH1 homologous phosphatase 2
    dual specificity protein phosphatase hVH2
    mitogen-activated protein kinase phosphatase 2
    serine/threonine specific protein phosphatase
    NP_001385.1
    NP_476499.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394.7NP_001385.1  dual specificity protein phosphatase 4 isoform 1

      See identical proteins and their annotated locations for NP_001385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AC084262, AK314820, AL137704, BC012900, DA645190
      Consensus CDS
      CCDS6072.1
      UniProtKB/Swiss-Prot
      B2RBU5, D3DSU4, G5E930, Q13115, Q13524
      UniProtKB/TrEMBL
      Q13649
      Related
      ENSP00000240100.2, ENST00000240100.7
      Conserved Domains (2) summary
      cd00127
      Location:195331
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:9158
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    2. NM_057158.4NP_476499.1  dual specificity protein phosphatase 4 isoform 2

      See identical proteins and their annotated locations for NP_476499.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084262, AL137704, BC012900
      Consensus CDS
      CCDS6073.1
      UniProtKB/Swiss-Prot
      Q13115
      Related
      ENSP00000240101.2, ENST00000240101.2
      Conserved Domains (1) summary
      cd00127
      Location:104240
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      29333064..29350684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      29611341..29628961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)