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    ME1 malic enzyme 1 [ Homo sapiens (human) ]

    Gene ID: 4199, updated on 11-Apr-2024

    Summary

    Official Symbol
    ME1provided by HGNC
    Official Full Name
    malic enzyme 1provided by HGNC
    Primary source
    HGNC:HGNC:6983
    See related
    Ensembl:ENSG00000065833 MIM:154250; AllianceGenome:HGNC:6983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MES; HUMNDME
    Summary
    This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 29.4), adrenal (RPKM 23.1) and 21 other tissues See more
    Orthologs
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    Genomic context

    See ME1 in Genome Data Viewer
    Location:
    6q14.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (83210402..83431051, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (84433644..84654257, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (83920121..84140770, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24783 Neighboring gene NANOG hESC enhancer GRCh37_chr6:83821047-83821571 Neighboring gene DOP1 leucine zipper like protein A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17356 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:83902947-83903446 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene MPRA-validated peak5928 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr6:84004031-84004257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17358 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:84140986-84142185 Neighboring gene serine protease 35 Neighboring gene synaptosome associated protein 91 Neighboring gene Sharpr-MPRA regulatory region 13924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17360

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables NAD binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables NADP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables electron transfer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables malate dehydrogenase (decarboxylating) (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables malic enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables malic enzyme activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxaloacetate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in NADH metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in NADP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in carbohydrate metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in malate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleotide biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of NADP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to carbohydrate TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    NADP-dependent malic enzyme
    Names
    Malic enzyme, cytoplasmic
    NADP-ME
    malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
    malic enzyme 1, NADP(+)-dependent, cytosolic
    malic enzyme 1, soluble
    pyruvic-malic carboxylase
    NP_002386.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002395.6NP_002386.1  NADP-dependent malic enzyme

      See identical proteins and their annotated locations for NP_002386.1

      Status: REVIEWED

      Source sequence(s)
      AL049699, BC025246, DA520723, KF458214
      Consensus CDS
      CCDS34492.1
      UniProtKB/Swiss-Prot
      B4DZ70, P48163, Q16797, Q16855, Q53F72, Q5VWA2, Q9BWX8, Q9H1W3, Q9UIY4
      UniProtKB/TrEMBL
      A8K168
      Related
      ENSP00000358719.3, ENST00000369705.4
      Conserved Domains (3) summary
      cd05312
      Location:270547
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:11551
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:79260
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      83210402..83431051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      84433644..84654257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)