Corin corin, serine peptidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Corinprovided by MGI
Official Full Name: corin, serine peptidaseprovided by MGI
Primary source: MGI:MGI:1349451
See related: Ensembl:ENSMUSG00000005220 AllianceGenome:MGI:1349451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lrp4
Summary: Enables serine-type endopeptidase activity. Involved in several processes, including peptide hormone processing; regulation of renal sodium excretion; and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Located in cell surface. Is expressed in several structures, including floor plate; heart; lip; phalanx; and skin. Human ortholog(s) of this gene implicated in hypertension and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 20.3), testis adult (RPKM 3.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.2; 5 38.44 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (72457291..72661884, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (72299948..72504540, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Corin protects against acute kidney injury in mice through anti-inflammatory effects.
Title: Corin protects against acute kidney injury in mice through anti-inflammatory effects.
Corin deficiency alleviates mucosal lesions in a mouse model of colitis induced by dextran sulfate sodium.
Title: Corin deficiency alleviates mucosal lesions in a mouse model of colitis induced by dextran sulfate sodium.
Overexpression of Corin Ameliorates Kidney Fibrosis through Inhibition of Wnt/beta-Catenin Signaling in Mice.
Title: Overexpression of Corin Ameliorates Kidney Fibrosis through Inhibition of Wnt/β-Catenin Signaling in Mice.
Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis.
Title: Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis.
A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.
Title: A common CORIN variant in hypertension reduces corin intracellular trafficking by exposing an inhibitory N-terminus.
Corin Overexpression Reduces Myocardial Infarct Size and Modulates Cardiomyocyte Apoptotic Cell Death.
Title: Corin Overexpression Reduces Myocardial Infarct Size and Modulates Cardiomyocyte Apoptotic Cell Death.
Kruppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
Title: Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
The protective effects of cardiac corin on HF progression and survival in experimental DCM do not require the serine protease activity of the molecule.
Title: Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy.
This is the first study to show that corin is a key regulator of bone development by modulation of VEGF-A expression.
Title: Corin is a key regulator of endochondral ossification and bone development via modulation of vascular endothelial growth factor A expression.
In mice, corin deficiency causes cardiac hypertrophy during pregnancy. Replacement of cardiac WT corin, but not the T555I/Q568P variant found in blacks, rescues this phenotype, indicating a local antihypertrophic function of corin in the heart. Corin deficiency may represent an underlying mechanism in preeclampsia-associated cardiomyopathies.
Title: Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AB013874 (e-PCR)
- UniSTS:163362

D5Mit305 (e-PCR), detects polymorphism
- UniSTS:116814

D5Mit305 (e-PCR), detects polymorphism
- UniSTS:130446

D5Buc20 (e-PCR), detects polymorphism
- UniSTS:142511

D5Buc22 (e-PCR), detects polymorphism
- UniSTS:142513

AU023070 (e-PCR)
- UniSTS:207794

D5Mit336 (e-PCR), detects polymorphism
- UniSTS:130482

BB498413 (e-PCR)
- UniSTS:207795

40.MMHAP25FRF10.seq (e-PCR)
- UniSTS:124361

AV273130 (e-PCR)
- UniSTS:179169

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in peptide hormone processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of renal sodium excretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of renal sodium excretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: atrial natriuretic peptide-converting enzyme

Names: low density lipoprotein receptor-related protein 4; low density lipoprotein-related protein 4; pro-ANP-converting enzyme

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122756.2 → NP_001116228.1 atrial natriuretic peptide-converting enzyme isoform 2

See identical proteins and their annotated locations for NP_001116228.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AC129608, AC161529

Consensus CDS

CCDS51513.1

UniProtKB/TrEMBL

H3BLB2

Related

ENSMUSP00000127389.3, ENSMUST00000167460.9

Conserved Domains (7) summary

cd07445
Location:136 → 265

CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

cd07888
Location:456 → 577

CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

smart00020
Location:802 → 1031

Tryp_SPc; Trypsin-like serine protease

smart00202
Location:692 → 787

SR; Scavenger receptor Cys-rich

cd00112
Location:657 → 691

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:803 → 1034

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:582 → 616

Ldl_recept_a; Low-density lipoprotein receptor domain class A
NM_001421227.1 → NP_001408156.1 atrial natriuretic peptide-converting enzyme isoform 3

Status: VALIDATED

Source sequence(s)

AC129608, AC161529
NM_016869.4 → NP_058565.2 atrial natriuretic peptide-converting enzyme isoform 1

See identical proteins and their annotated locations for NP_058565.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC129608, AC161529

Consensus CDS

CCDS19330.1

UniProtKB/Swiss-Prot

B2RRC6, Q566K6, Q9Z319

UniProtKB/TrEMBL

B7ZNH6

Related

ENSMUSP00000005352.4, ENSMUST00000005352.10

Conserved Domains (7) summary

cd07445
Location:202 → 331

CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

cd07888
Location:522 → 643

CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

smart00020
Location:868 → 1097

Tryp_SPc; Trypsin-like serine protease

smart00202
Location:758 → 853

SR; Scavenger receptor Cys-rich

cd00112
Location:723 → 757

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:869 → 1100

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:648 → 682

Ldl_recept_a; Low-density lipoprotein receptor domain class A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

72457291..72661884 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240755.1 → XP_011239057.1 atrial natriuretic peptide-converting enzyme isoform X1

UniProtKB/TrEMBL

H3BKS9

Conserved Domains (6) summary

cd07445
Location:136 → 264

CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

cd07888
Location:455 → 576

CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

smart00202
Location:691 → 786

SR; Scavenger receptor Cys-rich

cd00112
Location:656 → 690

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:802 → 1033

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:581 → 615

Ldl_recept_a; Low-density lipoprotein receptor domain class A