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    TNFSF15 TNF superfamily member 15 [ Homo sapiens (human) ]

    Gene ID: 9966, updated on 26-Jul-2021

    Summary

    Official Symbol
    TNFSF15provided by HGNC
    Official Full Name
    TNF superfamily member 15provided by HGNC
    Primary source
    HGNC:HGNC:11931
    See related
    Ensembl:ENSG00000181634 MIM:604052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TL1; TL1A; VEGI; TNLG1B; VEGI192A
    Summary
    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in duodenum (RPKM 4.3), urinary bladder (RPKM 3.6) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TNFSF15 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (114784635..114806039, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117546915..117568319, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene testis expressed 48 Neighboring gene uncharacterized LOC105376231 Neighboring gene pre-mRNA processing factor 4B pseudogene Neighboring gene TNF superfamily member 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
    GeneReviews: Not available
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    GeneReviews: Not available
    Genetic predictors of medically refractory ulcerative colitis.
    GeneReviews: Not available
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    GeneReviews: Not available
    Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
    GeneReviews: Not available
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    GeneReviews: Not available
    Genomewide association study of leprosy.
    GeneReviews: Not available
    HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease.
    GeneReviews: Not available
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.
    GeneReviews: Not available
    Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
    GeneReviews: Not available
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of tumor necrosis factor ligand superfamily, member 15 (TNFSF15) in Vif-expression T cells PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of TNFSF15 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC129934, MGC129935

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor ligand superfamily member 15
    Names
    TNF ligand-related molecule 1
    TNF superfamily ligand TL1A
    tumor necrosis factor (ligand) superfamily, member 15
    tumor necrosis factor ligand 1B
    tumor necrosis factor superfamily member 15
    vascular endothelial cell growth inhibitor
    vascular endothelial growth inhibitor-192A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011488.2 RefSeqGene

      Range
      5090..26477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204344.1NP_001191273.1  tumor necrosis factor ligand superfamily member 15 isoform VEGI-192

      See identical proteins and their annotated locations for NP_001191273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (VEGI-192) has a shorter and distinct N-terminus compared to isoform VEGI-251.
      Source sequence(s)
      AL390240, AW014795, AY434464
      UniProtKB/Swiss-Prot
      O95150
      Conserved Domains (1) summary
      pfam00229
      Location:58192
      TNF; TNF(Tumour Necrosis Factor) family
    2. NM_005118.4NP_005109.2  tumor necrosis factor ligand superfamily member 15 isoform VEGI-251 precursor

      See identical proteins and their annotated locations for NP_005109.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (VEGI-251).
      Source sequence(s)
      AL390240, BC104463
      Consensus CDS
      CCDS6809.1
      UniProtKB/Swiss-Prot
      O95150
      UniProtKB/TrEMBL
      A0A0U5JA19
      Related
      ENSP00000363157.3, ENST00000374045.5
      Conserved Domains (1) summary
      pfam00229
      Location:117251
      TNF; TNF(Tumour Necrosis Factor) family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      114784635..114806039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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