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    CDC25B cell division cycle 25B [ Homo sapiens (human) ]

    Gene ID: 994, updated on 5-Mar-2024

    Summary

    Official Symbol
    CDC25Bprovided by HGNC
    Official Full Name
    cell division cycle 25Bprovided by HGNC
    Primary source
    HGNC:HGNC:1726
    See related
    Ensembl:ENSG00000101224 MIM:116949; AllianceGenome:HGNC:1726
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 21.4), appendix (RPKM 15.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CDC25B in Genome Data Viewer
    Location:
    20p13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3786951..3806115)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3817891..3837037)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3767598..3786762)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3759113-3759730 Neighboring gene Sharpr-MPRA regulatory region 2213 Neighboring gene sperm flagellar 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3766083-3766793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3766794-3767503 Neighboring gene centromere protein B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3775953-3776684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12630 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:3777341-3777548 Neighboring gene Sharpr-MPRA regulatory region 3723 Neighboring gene Sharpr-MPRA regulatory region 8683 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:3782484-3783683 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3787799-3788390 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3788391-3788981 Neighboring gene long intergenic non-protein coding RNA 1730 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:3791796-3792995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12631 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3800994-3801697 Neighboring gene adaptor related protein complex 5 subunit sigma 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    EBI GWAS Catalog
    Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25 PubMed
    vpr HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein phosphatase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    M-phase inducer phosphatase 2
    Names
    CDC25 homolog B
    dual specificity phosphatase Cdc25B
    NP_001274445.1
    NP_001274446.1
    NP_001274447.1
    NP_001274448.1
    NP_001274449.1
    NP_001274451.1
    NP_001274453.1
    NP_004349.1
    NP_068658.1
    NP_068659.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029040.2 RefSeqGene

      Range
      14539..24344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001287516.2NP_001274445.1  M-phase inducer phosphatase 2 isoform 4

      See identical proteins and their annotated locations for NP_001274445.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an upstream start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK295573, AL109804, DA107932, DB477384
      Consensus CDS
      CCDS74700.1
      UniProtKB/TrEMBL
      B4DIG0, B4DQZ3, E9PCK4
      Related
      ENSP00000339125.6, ENST00000344256.10
      Conserved Domains (2) summary
      cd01530
      Location:348467
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:49319
      M-inducer_phosp; M-phase inducer phosphatase
    2. NM_001287517.2NP_001274446.1  M-phase inducer phosphatase 2 isoform 5

      See identical proteins and their annotated locations for NP_001274446.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR which results in initiation of translation at an upstream start codon, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK299192, AL109804, DA107932, DB477384
      UniProtKB/TrEMBL
      B4DQZ3, B4DRC3
      Conserved Domains (2) summary
      cd01530
      Location:334453
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:35305
      M-inducer_phosp; M-phase inducer phosphatase
    3. NM_001287518.2NP_001274447.1  M-phase inducer phosphatase 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, initiates translation at an upstream start codon, and lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 6) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK299028, AL109804, DA107932, DB477384
      Consensus CDS
      CCDS74701.1
      UniProtKB/TrEMBL
      B4DQZ3, G8JLH2
      Related
      ENSP00000368918.5, ENST00000379598.9
      Conserved Domains (2) summary
      cd01530
      Location:321440
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:49292
      M-inducer_phosp; M-phase inducer phosphatase
    4. NM_001287519.2NP_001274448.1  M-phase inducer phosphatase 2 isoform 7

      See identical proteins and their annotated locations for NP_001274448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in the 5' UTR which results in initiation of translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 7) has a shorter N-terminus compared to isoform 1. Variants 7 and 8 encode the same isoform.
      Source sequence(s)
      AL561439, BC051711, BM793120, BX647988
      UniProtKB/TrEMBL
      B3KS38, Q6MZW8
      Conserved Domains (2) summary
      cd01530
      Location:300419
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:1271
      M-inducer_phosp; M-phase inducer phosphatase
    5. NM_001287520.2NP_001274449.1  M-phase inducer phosphatase 2 isoform 7

      See identical proteins and their annotated locations for NP_001274449.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), also known as CDC25B6, uses an alternate splice site in the 5' UTR which results in initiation of translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 7) has a shorter N-terminus compared to isoform 1. Variants 7 and 8 encode the same isoform.
      Source sequence(s)
      DA107932, FR695900
      UniProtKB/TrEMBL
      B3KS38, Q6MZW8
      Conserved Domains (2) summary
      cd01530
      Location:300419
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:1271
      M-inducer_phosp; M-phase inducer phosphatase
    6. NM_001287522.2NP_001274451.1  M-phase inducer phosphatase 2 isoform 8

      See identical proteins and their annotated locations for NP_001274451.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site in the 5' UTR which results in initiation of translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 8) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL561439, FR695901
      UniProtKB/TrEMBL
      E1YMX4, Q6MZW8
      Conserved Domains (2) summary
      cd01530
      Location:259378
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:1230
      M-inducer_phosp; M-phase inducer phosphatase
    7. NM_001287524.2NP_001274453.1  M-phase inducer phosphatase 2 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, which causes translation initiation at a downstream start codon. The resulting protein (isoform 9) has a shorter N-terminus and lacks an internal region compared to isoform 1.
      Source sequence(s)
      AL109804, BC051711, BX640836, DA065196, DA107932
      UniProtKB/TrEMBL
      Q6MZW8
      Conserved Domains (2) summary
      cd01530
      Location:220339
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:1191
      M-inducer_phosp; M-phase inducer phosphatase
    8. NM_004358.5NP_004349.1  M-phase inducer phosphatase 2 isoform 2

      See identical proteins and their annotated locations for NP_004349.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as CDC25B1, uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      BC051711, BX640836, S78187
      Consensus CDS
      CCDS13065.1
      UniProtKB/TrEMBL
      B4DQZ3
      Related
      ENSP00000405972.2, ENST00000439880.6
      Conserved Domains (2) summary
      cd01530
      Location:398517
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:99369
      M-inducer_phosp; M-phase inducer phosphatase
    9. NM_021872.4NP_068658.1  M-phase inducer phosphatase 2 isoform 3

      See identical proteins and their annotated locations for NP_068658.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as CDC25B2, lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      BC051711, BX640836, S78187, Z68092
      Consensus CDS
      CCDS13066.1
      UniProtKB/TrEMBL
      B4DQZ3
      Related
      ENSP00000339170.4, ENST00000340833.4
      Conserved Domains (2) summary
      cd01530
      Location:371490
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:113342
      M-inducer_phosp; M-phase inducer phosphatase
    10. NM_021873.4NP_068659.1  M-phase inducer phosphatase 2 isoform 1

      See identical proteins and their annotated locations for NP_068659.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as CDC25B3, represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC051711, BX640836, S78187
      Consensus CDS
      CCDS13067.1
      UniProtKB/Swiss-Prot
      D3DVY1, D3DVY2, D3DVY3, D3DVY4, O43551, P30305, Q13971, Q5JX77, Q6RSS1, Q9BRA6
      UniProtKB/TrEMBL
      B4DQZ3
      Related
      ENSP00000245960.5, ENST00000245960.10
      Conserved Domains (2) summary
      cd01530
      Location:412531
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:113383
      M-inducer_phosp; M-phase inducer phosphatase

    RNA

    1. NR_136335.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109804, DA107932
    2. NR_136336.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109804, DA107932, DB477384

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      3786951..3806115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      3817891..3837037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021874.2: Suppressed sequence

      Description
      NM_021874.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_212530.1: Suppressed sequence

      Description
      NM_212530.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.