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    ARHGAP25 Rho GTPase activating protein 25 [ Homo sapiens (human) ]

    Gene ID: 9938, updated on 23-Nov-2021

    Summary

    Official Symbol
    ARHGAP25provided by HGNC
    Official Full Name
    Rho GTPase activating protein 25provided by HGNC
    Primary source
    HGNC:HGNC:28951
    See related
    Ensembl:ENSG00000163219 MIM:610587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAIA0053; HEL-S-308
    Summary
    ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in lymph node (RPKM 20.1), spleen (RPKM 18.9) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARHGAP25 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68710510..68826845)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68961943..69053965)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 1 pseudogene Neighboring gene prokineticin receptor 1 Neighboring gene Sharpr-MPRA regulatory region 5025 Neighboring gene uncharacterized LOC105374790 Neighboring gene CRISPRi-validated cis-regulatory element chr2.2482 Neighboring gene long intergenic non-protein coding RNA 1890 Neighboring gene long intergenic non-protein coding RNA 1888

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagocytosis, engulfment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in phagocytic cup IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in phagocytic cup IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rho GTPase-activating protein 25
    Names
    epididymis secretory protein Li 308
    epididymis secretory sperm binding protein
    rho-type GTPase-activating protein 25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007231.3NP_001007232.2  rho GTPase-activating protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC097495, AK290396, BC032222, CD695161
      Consensus CDS
      CCDS33214.2
      UniProtKB/Swiss-Prot
      P42331
      Related
      ENSP00000386911.3, ENST00000409202.8
      Conserved Domains (3) summary
      cd04390
      Location:156354
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:45157
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:47149
      PH; PH domain
    2. NM_001166276.2NP_001159748.1  rho GTPase-activating protein 25 isoform c

      See identical proteins and their annotated locations for NP_001159748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      BC032222
      Consensus CDS
      CCDS54364.1
      UniProtKB/Swiss-Prot
      P42331
      Related
      ENSP00000386241.1, ENST00000409220.5
      Conserved Domains (3) summary
      cd04390
      Location:149347
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:38150
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:40142
      PH; PH domain
    3. NM_001166277.2NP_001159749.1  rho GTPase-activating protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
      Source sequence(s)
      AC097495, AK297056, BC032222, CD695161
      Consensus CDS
      CCDS54363.1
      UniProtKB/Swiss-Prot
      P42331
      Related
      ENSP00000420583.1, ENST00000467265.5
      Conserved Domains (3) summary
      cd04390
      Location:117314
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      pfam00169
      Location:47115
      PH; PH domain
      cl17171
      Location:45120
      PH-like; Pleckstrin homology-like domain
    4. NM_001364819.1NP_001351748.1  rho GTPase-activating protein 25 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC097495, AK290396, BC032222, CD695161, DA462915
      Conserved Domains (3) summary
      cd04390
      Location:155353
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:45155
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      cl25732
      Location:544644
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001364820.1NP_001351749.1  rho GTPase-activating protein 25 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC097495, AK297056, BC032222, BX340497, CD695161
      Conserved Domains (3) summary
      cd04390
      Location:117315
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cl17171
      Location:45122
      PH-like; Pleckstrin homology-like domain
      cl25732
      Location:506606
      SMC_N; RecF/RecN/SMC N terminal domain
    6. NM_001364821.1NP_001351750.1  rho GTPase-activating protein 25 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC097495, AK297056, BC032222, CR991724, DB243756
      Conserved Domains (3) summary
      cd04390
      Location:130328
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:19131
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      cl25732
      Location:519619
      SMC_N; RecF/RecN/SMC N terminal domain
    7. NM_014882.3NP_055697.1  rho GTPase-activating protein 25 isoform b

      See identical proteins and their annotated locations for NP_055697.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      BC032222, D29642
      Consensus CDS
      CCDS46312.1
      UniProtKB/Swiss-Prot
      P42331
      UniProtKB/TrEMBL
      V9HWC8
      Related
      ENSP00000386863.3, ENST00000409030.7
      Conserved Domains (3) summary
      cd04390
      Location:148346
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:38148
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:40142
      PH; PH domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      68710510..68826845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533207.3XP_011531509.1  rho GTPase-activating protein 25 isoform X4

      See identical proteins and their annotated locations for XP_011531509.1

      Conserved Domains (3) summary
      cd04390
      Location:130328
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:19131
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      cl25732
      Location:519619
      SMC_N; RecF/RecN/SMC N terminal domain
    2. XM_011533208.2XP_011531510.1  rho GTPase-activating protein 25 isoform X4

      See identical proteins and their annotated locations for XP_011531510.1

      Conserved Domains (3) summary
      cd04390
      Location:130328
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
      cd13263
      Location:19131
      PH_RhoGap25-like; Rho GTPase activating protein 25 and related proteins Pleckstrin homology (PH) domain
      cl25732
      Location:519619
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_017005423.2XP_016860912.1  rho GTPase-activating protein 25 isoform X1

    4. XM_017005424.1XP_016860913.1  rho GTPase-activating protein 25 isoform X2

    5. XM_017005425.1XP_016860914.1  rho GTPase-activating protein 25 isoform X5

    6. XM_017005428.1XP_016860917.1  rho GTPase-activating protein 25 isoform X9

      Related
      ENSP00000417283.1, ENST00000463483.5
    7. XM_011533209.2XP_011531511.1  rho GTPase-activating protein 25 isoform X7

      Related
      ENSP00000417818.1, ENST00000497259.5
      Conserved Domains (1) summary
      cd04390
      Location:38236
      RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    8. XM_017005426.1XP_016860915.1  rho GTPase-activating protein 25 isoform X8

      Conserved Domains (1) summary
      cl02570
      Location:180
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    9. XM_017005427.1XP_016860916.1  rho GTPase-activating protein 25 isoform X8

      Conserved Domains (1) summary
      cl02570
      Location:180
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    10. XM_011533210.3XP_011531512.1  rho GTPase-activating protein 25 isoform X8

      Related
      ENSP00000417467.1, ENST00000479844.1
      Conserved Domains (1) summary
      cl02570
      Location:180
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
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