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    Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 99371, updated on 12-May-2024

    Summary

    Official Symbol
    Arfgef2provided by MGI
    Official Full Name
    ADP ribosylation factor guanine nucleotide exchange factor 2provided by MGI
    Primary source
    MGI:MGI:2139354
    See related
    Ensembl:ENSMUSG00000074582 AllianceGenome:MGI:2139354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BIG2; E230011G24Rik
    Summary
    Predicted to enable several functions, including GABA receptor binding activity; guanyl-nucleotide exchange factor activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; positive regulation of tumor necrosis factor production; and receptor recycling. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and recycling endosome. Is expressed in brown fat; central nervous system; duodenum; thymus; and trunk. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 9.9), lung adult (RPKM 8.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arfgef2 in Genome Data Viewer
    Location:
    2 H3; 2 87.22 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166647371..166739972)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166805451..166898052)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31117 Neighboring gene STARR-positive B cell enhancer ABC_E6021 Neighboring gene transformation related protein 53 regulating kinase B Neighboring gene STARR-positive B cell enhancer ABC_E10161 Neighboring gene STARR-positive B cell enhancer ABC_E2654 Neighboring gene STARR-seq mESC enhancer starr_06416 Neighboring gene STARR-positive B cell enhancer ABC_E2655 Neighboring gene predicted gene, 31204 Neighboring gene chromosome segregation 1 like Neighboring gene staufen double-stranded RNA binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9541

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endomembrane system organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in symmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    brefeldin A-inhibited guanine nucleotide-exchange protein 2
    Names
    ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
    brefeldin A-inhibited GEP 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085495.2NP_001078964.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2

      See identical proteins and their annotated locations for NP_001078964.1

      Status: VALIDATED

      Source sequence(s)
      AL591703, AL591911
      Consensus CDS
      CCDS38335.1
      UniProtKB/Swiss-Prot
      A2A5R2
      Related
      ENSMUSP00000096677.4, ENSMUST00000099078.10
      Conserved Domains (1) summary
      PLN03076
      Location:111718
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      166647371..166739972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500484.4XP_006500547.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2

      Conserved Domains (1) summary
      PLN03076
      Location:111695
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    2. XM_006500483.4XP_006500546.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1

      Conserved Domains (1) summary
      PLN03076
      Location:111717
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    3. XM_036162763.1XP_036018656.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X3

      Conserved Domains (1) summary
      PLN03076
      Location:111694
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
    4. XM_030252278.2XP_030108138.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X4

      Conserved Domains (1) summary
      PLN03076
      Location:1891530
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional