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    Arfgef2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) [ Mus musculus (house mouse) ]

    Gene ID: 99371, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arfgef2provided by MGI
    Official Full Name
    ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)provided by MGI
    Primary source
    MGI:MGI:2139354
    See related
    Ensembl:ENSMUSG00000074582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BIG2; AI463430; AW493672; E230011G24Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 9.9), lung adult (RPKM 8.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arfgef2 in Genome Data Viewer
    Location:
    2; 2 H3
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (166805463..166898052)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (166631081..166723552)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31117 Neighboring gene transformation related protein 53 regulating kinase B Neighboring gene predicted gene, 31204 Neighboring gene chromosome segregation 1-like (S. cerevisiae)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ARF guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ARF guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    endomembrane system organization ISO
    Inferred from Sequence Orthology
    more info
     
    endosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    symmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    brefeldin A-inhibited guanine nucleotide-exchange protein 2
    Names
    brefeldin A-inhibited GEP 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085495.2NP_001078964.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2

      See identical proteins and their annotated locations for NP_001078964.1

      Status: VALIDATED

      Source sequence(s)
      AL591703, AL591911
      Consensus CDS
      CCDS38335.1
      UniProtKB/Swiss-Prot
      A2A5R2
      Related
      ENSMUSP00000096677.3, ENSMUST00000099078.9
      Conserved Domains (5) summary
      PLN03076
      Location:111718
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:650834
      Sec7; Sec7 domain
      pfam09324
      Location:11741255
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:377531
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:28198
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      166805463..166898052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500483.3XP_006500546.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1

      Conserved Domains (5) summary
      PLN03076
      Location:111717
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:649833
      Sec7; Sec7 domain
      pfam09324
      Location:11731254
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:376530
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:28198
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    2. XM_006500484.3XP_006500547.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2

      Conserved Domains (5) summary
      PLN03076
      Location:111695
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:627811
      Sec7; Sec7 domain
      pfam09324
      Location:11511232
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:354508
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:28198
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    3. XM_011239875.1XP_011238177.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X3

      Conserved Domains (4) summary
      COG5307
      Location:1741276
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:439623
      Sec7; Sec7 domain
      pfam09324
      Location:9631044
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:166320
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
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