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    Anapc2 anaphase promoting complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 99152, updated on 31-Jan-2019

    Summary

    Official Symbol
    Anapc2provided by MGI
    Official Full Name
    anaphase promoting complex subunit 2provided by MGI
    Primary source
    MGI:MGI:2139135
    See related
    Ensembl:ENSMUSG00000026965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apc2; Emi4; Imi4; AL024279; mKIAA1406; 9230107K09Rik
    Summary
    This gene encodes a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle by ubiquitinating its specific substrates, such as mitotic cyclins and anaphase inhibitor, for subsequent degradation by the proteasome. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in ovary adult (RPKM 38.6), limb E14.5 (RPKM 34.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Anapc2 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (25272466..25285916)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (25127986..25141436)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene taperin Neighboring gene SS nuclear autoantigen 1 Neighboring gene transmembrane protein 210 Neighboring gene leucine rich repeat containing 26 Neighboring gene glutamate receptor, ionotropic, NMDA1 (zeta 1)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synapse maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synaptic plasticity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 2
    Names
    cyclosome subunit 2
    expressed during mesenchymal induction 4
    induced during mesenchymal induction 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175300.4NP_780509.2  anaphase-promoting complex subunit 2

      See identical proteins and their annotated locations for NP_780509.2

      Status: REVIEWED

      Source sequence(s)
      AA727217, AK033784, CJ072758, CJ164053, CR520037
      Consensus CDS
      CCDS15761.1
      UniProtKB/Swiss-Prot
      Q8BZQ7
      Related
      ENSMUSP00000028341.4, ENSMUST00000028341.10
      Conserved Domains (2) summary
      smart01013
      Location:772832
      APC2; Anaphase promoting complex (APC) subunit 2
      smart00182
      Location:524657
      CULLIN; Cullin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      25272466..25285916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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