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    SUPT7L SPT7 like, STAGA complex subunit gamma [ Homo sapiens (human) ]

    Gene ID: 9913, updated on 5-Mar-2024

    Summary

    Official Symbol
    SUPT7Lprovided by HGNC
    Official Full Name
    SPT7 like, STAGA complex subunit gammaprovided by HGNC
    Primary source
    HGNC:HGNC:30632
    See related
    Ensembl:ENSG00000119760 MIM:612762; AllianceGenome:HGNC:30632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPT7L; STAF65; SUPT7H; STAF65G; STAF65(gamma)
    Summary
    SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
    Expression
    Ubiquitous expression in brain (RPKM 10.8), spleen (RPKM 8.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SUPT7L in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27642568..27663614, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27685653..27706702, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27873676..27886481, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15511 Neighboring gene coiled-coil domain containing 121 Neighboring gene GPN-loop GTPase 1 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27875474-27876673 Neighboring gene solute carrier family 4 member 1 adaptor protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27904532-27905731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11303 Neighboring gene long intergenic non-protein coding RNA 1460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11304

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0764, MGC90306

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    STAGA complex 65 subunit gamma
    Names
    SPT7 like, STAGA complex gamma subunit
    SPTF-associated factor 65 gamma
    STAF65gamma
    STAGA complex 65 gamma subunit
    adenocarcinoma antigen ART1
    suppressor of Ty 7-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282729.2NP_001269658.1  STAGA complex 65 subunit gamma isoform a

      See identical proteins and their annotated locations for NP_001269658.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AB018307, AC074091, BC074000, CF528942, DA398215
      Consensus CDS
      CCDS42667.1
      UniProtKB/Swiss-Prot
      B4E3W3, O94864, Q6IB21, Q9H2T6
      Conserved Domains (1) summary
      smart00576
      Location:151226
      BTP; Bromodomain transcription factors and PHD domain containing proteins
    2. NM_001282730.2NP_001269659.1  STAGA complex 65 subunit gamma isoform b

      See identical proteins and their annotated locations for NP_001269659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform b.
      Source sequence(s)
      AB018307, AC074091, BC045638, CF528942, DA398215
      Consensus CDS
      CCDS62885.1
      UniProtKB/Swiss-Prot
      O94864
      Related
      ENSP00000384469.1, ENST00000405491.5
      Conserved Domains (1) summary
      smart00576
      Location:149224
      BTP; Bromodomain transcription factors and PHD domain containing proteins
    3. NM_001282731.2NP_001269660.1  STAGA complex 65 subunit gamma isoform b

      See identical proteins and their annotated locations for NP_001269660.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform b.
      Source sequence(s)
      AB018307, AC074091, AF197954, BI755200, CF528942, DA001757
      Consensus CDS
      CCDS62885.1
      UniProtKB/Swiss-Prot
      O94864
      Conserved Domains (1) summary
      smart00576
      Location:149224
      BTP; Bromodomain transcription factors and PHD domain containing proteins
    4. NM_001282732.2NP_001269661.1  STAGA complex 65 subunit gamma isoform c

      See identical proteins and their annotated locations for NP_001269661.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AB018307, AC074091, AK304889, CF528942
      Consensus CDS
      CCDS62886.1
      UniProtKB/Swiss-Prot
      O94864
      Related
      ENSP00000385218.2, ENST00000404798.6
      Conserved Domains (1) summary
      smart00576
      Location:1691
      BTP; Bromodomain transcription factors and PHD domain containing proteins
    5. NM_014860.3NP_055675.1  STAGA complex 65 subunit gamma isoform a

      See identical proteins and their annotated locations for NP_055675.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AB018307, AC074091, AF197954, CF528942, DA398215
      Consensus CDS
      CCDS42667.1
      UniProtKB/Swiss-Prot
      B4E3W3, O94864, Q6IB21, Q9H2T6
      Related
      ENSP00000336750.5, ENST00000337768.10
      Conserved Domains (1) summary
      smart00576
      Location:151226
      BTP; Bromodomain transcription factors and PHD domain containing proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27642568..27663614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264672.5XP_005264729.1  STAGA complex 65 subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_005264729.1

      UniProtKB/Swiss-Prot
      O94864
      Conserved Domains (1) summary
      smart00576
      Location:149224
      BTP; Bromodomain transcription factors and PHD domain containing proteins

    RNA

    1. XR_939750.4 RNA Sequence

    2. XR_007085624.1 RNA Sequence

    3. XR_007085611.1 RNA Sequence

    4. XR_007085617.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27685653..27706702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344774.1XP_054200749.1  STAGA complex 65 subunit gamma isoform X1

    RNA

    1. XR_008486607.1 RNA Sequence

    2. XR_008486610.1 RNA Sequence

    3. XR_008486608.1 RNA Sequence

    4. XR_008486609.1 RNA Sequence