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    CDC20 cell division cycle 20 [ Homo sapiens (human) ]

    Gene ID: 991, updated on 17-Jun-2024

    Summary

    Official Symbol
    CDC20provided by HGNC
    Official Full Name
    cell division cycle 20provided by HGNC
    Primary source
    HGNC:HGNC:1723
    See related
    Ensembl:ENSG00000117399 MIM:603618; AllianceGenome:HGNC:1723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC20A; OOMD14; p55CDC; OZEMA14; bA276H19.3
    Summary
    CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 26.5), bone marrow (RPKM 19.7) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CDC20 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43358981..43363203)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43229529..43233751)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43824652..43828874)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:43813871-43814842 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:43814843-43815813 Neighboring gene CDC20 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:43823421-43823929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 916 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:43824440-43824948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:43832389-43833123 Neighboring gene ELOVL fatty acid elongase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:43833124-43833858 Neighboring gene microRNA 6734 Neighboring gene uncharacterized LOC112268225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 917 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:43834951-43835136 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:43838300-43839499 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:43844005-43844173

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of cell division cycle 20 (CDC20) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102824

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables anaphase-promoting complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metaphase/anaphase transition of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in metaphase/anaphase transition of meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitotic metaphase/anaphase transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of mitotic checkpoint complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in spindle TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cell division cycle protein 20 homolog
    Names
    CDC20 cell division cycle 20 homolog
    cell division cycle 20 homolog
    fizzy homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001255.3NP_001246.2  cell division cycle protein 20 homolog

      See identical proteins and their annotated locations for NP_001246.2

      Status: REVIEWED

      Source sequence(s)
      BC001088
      Consensus CDS
      CCDS484.1
      UniProtKB/Swiss-Prot
      B2R6Z6, D3DPJ1, Q12834, Q5JUY4, Q9BW56, Q9UQI9
      UniProtKB/TrEMBL
      B4E1H5
      Related
      ENSP00000308450.5, ENST00000310955.11
      Conserved Domains (2) summary
      cd00200
      Location:190471
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:229266
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      43358981..43363203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      43229529..43233751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)