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    KLHL21 kelch like family member 21 [ Homo sapiens (human) ]

    Gene ID: 9903, updated on 17-Jun-2024

    Summary

    Official Symbol
    KLHL21provided by HGNC
    Official Full Name
    kelch like family member 21provided by HGNC
    Primary source
    HGNC:HGNC:29041
    See related
    Ensembl:ENSG00000162413 MIM:616262; AllianceGenome:HGNC:29041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables cullin family protein binding activity. Contributes to ubiquitin-protein transferase activity. Involved in chromosome passenger complex localization to spindle midzone; protein ubiquitination; and regulation of cytokinesis. Located in polar microtubule. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in fat (RPKM 17.4), ovary (RPKM 14.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See KLHL21 in Genome Data Viewer
    Location:
    1p36.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6590724..6602869, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (6116388..6128533, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6650784..6662929, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene taste 1 receptor member 1 Neighboring gene uncharacterized LOC107984912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6639438-6640137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 83 Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:6658990-6660189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 84 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 85 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 86 Neighboring gene uncharacterized LOC107984913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 87 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 88 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6664299-6664647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 170 Neighboring gene PHD finger protein 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0469, MGC99635

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cullin family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome passenger complex localization to spindle midzone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in polar microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324309.2NP_001311238.1  kelch-like protein 21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL591866
      Related
      ENSP00000366891.3, ENST00000377663.3
      Conserved Domains (5) summary
      PHA03098
      Location:49493
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:326368
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:25130
      BTB; BTB/POZ domain
      pfam01344
      Location:327368
      Kelch_1; Kelch motif
      pfam07707
      Location:138239
      BACK; BTB And C-terminal Kelch
    2. NM_014851.4NP_055666.2  kelch-like protein 21 isoform 1

      See identical proteins and their annotated locations for NP_055666.2

      Status: VALIDATED

      Source sequence(s)
      AB007938, BC064980
      Consensus CDS
      CCDS30575.1
      UniProtKB/Swiss-Prot
      B3KQP2, O75057, Q5SY26, Q5SY28, Q8N4I6, Q8NF10, Q9UJP4
      Related
      ENSP00000366886.4, ENST00000377658.8
      Conserved Domains (7) summary
      smart00612
      Location:482512
      Kelch; Kelch domain
      PHA03098
      Location:49547
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:326368
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:25130
      BTB; BTB/POZ domain
      pfam01344
      Location:327368
      Kelch_1; Kelch motif
      pfam07707
      Location:138239
      BACK; BTB And C-terminal Kelch
      pfam13964
      Location:502549
      Kelch_6; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      6590724..6602869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      6116388..6128533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)