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    Eeig1 estrogen-induced osteoclastogenesis regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 98952, updated on 27-Nov-2024

    Summary

    Official Symbol
    Eeig1provided by MGI
    Official Full Name
    estrogen-induced osteoclastogenesis regulator 1provided by MGI
    Primary source
    MGI:MGI:2138935
    See related
    Ensembl:ENSMUSG00000039157 AllianceGenome:MGI:2138935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam102a; C230093N12Rik
    Summary
    Involved in positive regulation of osteoclast differentiation. Located in cytoplasm; membrane raft; and nucleus. Is expressed in craniocervical region bone; heart ventricle; submandibular gland primordium; and thoracic segment skeleton. Orthologous to human EEIG1 (estrogen-induced osteoclastogenesis regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 39.9), colon adult (RPKM 39.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eeig1 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32425344..32459763)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32535359..32569750)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13413 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Neighboring gene STARR-positive B cell enhancer ABC_E4433 Neighboring gene STARR-positive B cell enhancer ABC_E120 Neighboring gene STARR-seq mESC enhancer starr_04193 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E4434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32350767-32351080 Neighboring gene STARR-seq mESC enhancer starr_04196 Neighboring gene STARR-seq mESC enhancer starr_04197 Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene RIKEN cDNA 9430097D07 gene Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC38572

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in positive regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    early estrogen-induced gene 1 protein
    Names
    family with sequence similarity 102, member A
    protein FAM102A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153560.5NP_705788.1  early estrogen-induced gene 1 protein

      See identical proteins and their annotated locations for NP_705788.1

      Status: VALIDATED

      Source sequence(s)
      AL928710
      Consensus CDS
      CCDS15917.1
      UniProtKB/Swiss-Prot
      Q78T81, Q8K2K5
      UniProtKB/TrEMBL
      A0A158RFU0
      Related
      ENSMUSP00000044731.6, ENSMUST00000048375.6
      Conserved Domains (1) summary
      pfam10358
      Location:12152
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32425344..32459763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)