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    Ehd4 EH-domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 98878, updated on 5-Aug-2018

    Summary

    Official Symbol
    Ehd4provided by MGI
    Official Full Name
    EH-domain containing 4provided by MGI
    Primary source
    MGI:MGI:1919619
    See related
    Ensembl:ENSMUSG00000027293 Vega:OTTMUSG00000015289
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Past2; AI197390; AI846352; AV006278; 2210022F10Rik
    Expression
    Broad expression in lung adult (RPKM 115.2), heart adult (RPKM 78.1) and 16 other tissues See more
    Orthologs

    Genomic context

    See Ehd4 in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (120089487..120154575, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (119915223..119980311, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 28042 Neighboring gene phospholipase A2, group IVB (cytosolic) Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene phospholipase A2, group IVE Neighboring gene phospholipase A2, group IVD

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    pinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    EH domain-containing protein 4
    Names
    EH domain containing protein MPAST2
    PAST homolog 2
    mPAST2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133838.4NP_598599.2  EH domain-containing protein 4

      See identical proteins and their annotated locations for NP_598599.2

      Status: PROVISIONAL

      Source sequence(s)
      AL833774
      Consensus CDS
      CCDS16615.1
      UniProtKB/Swiss-Prot
      Q9EQP2
      UniProtKB/TrEMBL
      Q3TM70
      Related
      ENSMUSP00000028755.7, OTTMUSP00000016279, ENSMUST00000028755.7, OTTMUST00000036244
      Conserved Domains (4) summary
      smart00027
      Location:441534
      EH; Eps15 homology domain
      cd09913
      Location:63303
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:451515
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam16880
      Location:2759
      EHD_N; N-terminal EH-domain containing protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      120089487..120154575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319352.1XP_017174841.1  EH domain-containing protein 4 isoform X1

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