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    Rab3gap2 RAB3 GTPase activating protein subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 98732, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rab3gap2provided by MGI
    Official Full Name
    RAB3 GTPase activating protein subunit 2provided by MGI
    Primary source
    MGI:MGI:1916043
    See related
    Ensembl:ENSMUSG00000039318 Vega:OTTMUSG00000050654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI851069; AW743433; mKIAA0839; 5830469C09; RAB3-GAP150; 1110059F07Rik; 2010002H18Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 9.3), cortex adult (RPKM 8.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rab3gap2 in Genome Data Viewer
    Location:
    1; 1 H5
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (185204087..185286746)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (187028047..187110625)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34732 Neighboring gene predicted gene, 37662 Neighboring gene predicted gene, 34797 Neighboring gene small nucleolar RNA, H/ACA box 36B Neighboring gene predicted gene, 34882 Neighboring gene microRNA 664 Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 194-1 Neighboring gene microRNA 215

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rab guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to Rab guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    establishment of protein localization to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein lipidation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rab3 GTPase-activating protein non-catalytic subunit
    Names
    Rab3 GTPase-activating protein 150 kDa subunit
    Rab3-GAP regulatory subunit
    rab3-GAP p150

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163754.1NP_001157226.1  rab3 GTPase-activating protein non-catalytic subunit

      Status: VALIDATED

      Source sequence(s)
      AC131084, AC158963, AK031191, AK037092, AK149265, BB870581, BQ176759, CN459207
      Consensus CDS
      CCDS48478.1
      UniProtKB/Swiss-Prot
      Q8BMG7
      UniProtKB/TrEMBL
      E9QKE4, Q3UEY3, Q8BYZ6
      Related
      ENSMUSP00000066325.6, OTTMUSP00000069079, ENSMUST00000069652.7, OTTMUST00000128410
      Conserved Domains (2) summary
      pfam14655
      Location:73497
      RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus
      pfam14656
      Location:7791365
      RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      185204087..185286746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497216.3XP_006497279.1  rab3 GTPase-activating protein non-catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A0A6YWM5
      Related
      ENSMUSP00000141608.1, OTTMUSP00000069080, ENSMUST00000194740.5, OTTMUST00000128414
      Conserved Domains (2) summary
      pfam14655
      Location:73497
      RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus
      pfam14656
      Location:7791345
      RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172649.1: Suppressed sequence

      Description
      NM_172649.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: RAB3GAP2 (GeneID:25782).
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