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    Mael maelstrom spermatogenic transposon silencer [ Mus musculus (house mouse) ]

    Gene ID: 98558, updated on 27-Nov-2024

    Summary

    Official Symbol
    Maelprovided by MGI
    Official Full Name
    maelstrom spermatogenic transposon silencerprovided by MGI
    Primary source
    MGI:MGI:2138453
    See related
    Ensembl:ENSMUSG00000040629 AllianceGenome:MGI:2138453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933405K18Rik
    Summary
    Predicted to enable sequence-specific DNA binding activity. Involved in piRNA processing and retrotransposon silencing by piRNA-directed DNA methylation. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; meiotic nuclear division; and negative regulation of macromolecule biosynthetic process. Located in several cellular components, including chromosome; cytoplasmic ribonucleoprotein granule; and male germ cell nucleus. Is expressed in brain; early conceptus; and genitourinary system. Orthologous to human MAEL (maelstrom spermatogenic transposon silencer). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 282.2) See more
    Orthologs
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    Genomic context

    See Mael in Genome Data Viewer
    Location:
    1 H2.3; 1 73.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (166028954..166066313, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (166201385..166238744, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine/threonine/tyrosine interacting like 2 Neighboring gene STARR-seq mESC enhancer starr_02920 Neighboring gene STARR-positive B cell enhancer ABC_E7772 Neighboring gene glycoprotein A33 transmembrane Neighboring gene STARR-seq mESC enhancer starr_02926 Neighboring gene immunoglobulin-like domain containing receptor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:168290436-168290736 Neighboring gene STARR-seq mESC enhancer starr_02930 Neighboring gene STARR-positive B cell enhancer ABC_E11695 Neighboring gene transcriptional adaptor 1 Neighboring gene pogo transposable element with KRAB domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of developmental process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of miRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulatory ncRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transposable element silencing by piRNA-mediated DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in autosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatoid body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in piP-body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein maelstrom homolog
    Names
    maelstrom homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175296.4NP_780505.1  protein maelstrom homolog

      See identical proteins and their annotated locations for NP_780505.1

      Status: VALIDATED

      Source sequence(s)
      AC034122
      Consensus CDS
      CCDS15448.1
      UniProtKB/Swiss-Prot
      Q8BVN9
      UniProtKB/TrEMBL
      A0A0A6YWQ9
      Related
      ENSMUSP00000045828.4, ENSMUST00000038782.4
      Conserved Domains (2) summary
      pfam09011
      Location:572
      HMG_box_2; HMG-box domain
      pfam13017
      Location:130326
      Maelstrom; piRNA pathway germ-plasm component

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      166028954..166066313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)