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    ZNF623 zinc finger protein 623 [ Homo sapiens (human) ]

    Gene ID: 9831, updated on 5-Mar-2024

    Summary

    Official Symbol
    ZNF623provided by HGNC
    Official Full Name
    zinc finger protein 623provided by HGNC
    Primary source
    HGNC:HGNC:29084
    See related
    Ensembl:ENSG00000183309 AllianceGenome:HGNC:29084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 5.7), thyroid (RPKM 4.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    8q24.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143636019..143653730)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144785446..144802812)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144718189..144735900)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144699896-144700500 Neighboring gene uncharacterized LOC105375798 Neighboring gene GDP-L-fucose synthase Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105375799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751216-144751716 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144751717-144752217 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:144764224-144764449 Neighboring gene zinc finger protein 707

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103965, MGC104128

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082480.2NP_001075949.1  zinc finger protein 623 isoform 2

      See identical proteins and their annotated locations for NP_001075949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB014528, BC112898
      Consensus CDS
      CCDS47931.1
      UniProtKB/Swiss-Prot
      O75123
      UniProtKB/TrEMBL
      A0A0A0MT18
      Related
      ENSP00000411139.2, ENST00000458270.2
      Conserved Domains (4) summary
      COG5048
      Location:83454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:210234
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001261843.2NP_001248772.1  zinc finger protein 623 isoform 2

      See identical proteins and their annotated locations for NP_001248772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB014528, AK294695, DC355766, DC380463
      Consensus CDS
      CCDS47931.1
      UniProtKB/Swiss-Prot
      O75123
      UniProtKB/TrEMBL
      A0A0A0MT18
      Related
      ENSP00000435232.1, ENST00000526926.6
      Conserved Domains (4) summary
      COG5048
      Location:83454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:210234
      zf-H2C2_2; Zinc-finger double domain
    3. NM_014789.3NP_055604.3  zinc finger protein 623 isoform 1

      See identical proteins and their annotated locations for NP_055604.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC067516, BC067517, BX477157, DA100931, DA211779, DB161675, DB227885
      Consensus CDS
      CCDS34957.1
      UniProtKB/Swiss-Prot
      A4FU80, B4DGP3, E7ENV5, O75123
      Related
      ENSP00000445979.1, ENST00000501748.3
      Conserved Domains (2) summary
      COG5048
      Location:123494
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293313
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143636019..143653730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422501.1XP_047278457.1  zinc finger protein 623 isoform X1

    2. XM_006716708.4XP_006716771.1  zinc finger protein 623 isoform X1

      See identical proteins and their annotated locations for XP_006716771.1

      UniProtKB/TrEMBL
      A0A0A0MT18
      Conserved Domains (4) summary
      COG5048
      Location:83454
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251273
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:210234
      zf-H2C2_2; Zinc-finger double domain
    3. XM_047422498.1XP_047278454.1  zinc finger protein 623 isoform X1

    4. XM_047422499.1XP_047278455.1  zinc finger protein 623 isoform X1

    5. XM_047422500.1XP_047278456.1  zinc finger protein 623 isoform X1

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      111849..129199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328782.1XP_054184757.1  zinc finger protein 623 isoform X1

    2. XM_054328781.1XP_054184756.1  zinc finger protein 623 isoform X1

    3. XM_054328778.1XP_054184753.1  zinc finger protein 623 isoform X1

    4. XM_054328779.1XP_054184754.1  zinc finger protein 623 isoform X1

    5. XM_054328783.1XP_054184758.1  zinc finger protein 623 isoform X1

    6. XM_054328780.1XP_054184755.1  zinc finger protein 623 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144785446..144802812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361635.1XP_054217610.1  zinc finger protein 623 isoform X1

    2. XM_054361634.1XP_054217609.1  zinc finger protein 623 isoform X1

    3. XM_054361633.1XP_054217608.1  zinc finger protein 623 isoform X1

    4. XM_054361636.1XP_054217611.1  zinc finger protein 623 isoform X1

    5. XM_054361632.1XP_054217607.1  zinc finger protein 623 isoform X2