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    ARMCX2 armadillo repeat containing X-linked 2 [ Homo sapiens (human) ]

    Gene ID: 9823, updated on 23-Nov-2021

    Summary

    Official Symbol
    ARMCX2provided by HGNC
    Official Full Name
    armadillo repeat containing X-linked 2provided by HGNC
    Primary source
    HGNC:HGNC:16869
    See related
    Ensembl:ENSG00000184867 MIM:300363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALEX2; GASP9
    Summary
    This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in thyroid (RPKM 33.9), ovary (RPKM 22.0) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARMCX2 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (101655281..101659878, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100910267..100914835, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing X-linked 3 Neighboring gene RNA, U6 small nuclear 30, pseudogene Neighboring gene mitochondrial fission factor pseudogene Neighboring gene RNA, U6 small nuclear 587, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC8742, KIAA0512, MGC13343

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    armadillo repeat-containing X-linked protein 2
    Names
    ARM protein lost in epithelial cancers on chromosome X 2
    armadillo repeat protein ALEX2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013221.2 RefSeqGene

      Range
      5029..9598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282231.2NP_001269160.1  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_001269160.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC234775, BC015926, BG548388, BX648494, CN391032
      Consensus CDS
      CCDS14490.1
      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    2. NM_014782.7NP_055597.1  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_055597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC234775, BC012541, BC015926, BG548388
      Consensus CDS
      CCDS14490.1
      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Related
      ENSP00000331662.5, ENST00000328766.9
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    3. NM_177949.4NP_808818.1  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_808818.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC234775, AK291342, BC015926
      Consensus CDS
      CCDS14490.1
      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7, A8K5M7
      Related
      ENSP00000349281.4, ENST00000356824.9
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      101655281..101659878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005278113.1XP_005278170.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005278170.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    2. XM_005278115.1XP_005278172.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005278172.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    3. XM_005278114.1XP_005278171.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005278171.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    4. XM_017029991.1XP_016885480.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    5. XM_005278117.1XP_005278174.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005278174.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    6. XM_005278111.1XP_005278168.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005278168.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    7. XM_005278110.1XP_005278167.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005278167.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    8. XM_011531071.1XP_011529373.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011529373.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    9. XM_005278116.1XP_005278173.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005278173.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    10. XM_017029990.1XP_016885479.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    11. XM_005278109.1XP_005278166.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005278166.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    12. XM_017029992.1XP_016885481.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    13. XM_011531072.1XP_011529374.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011529374.1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    14. XM_024452483.1XP_024308251.1  armadillo repeat-containing X-linked protein 2 isoform X1

      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    15. XM_017029988.2XP_016885477.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    16. XM_017029987.2XP_016885476.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    17. XM_017029994.1XP_016885483.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Related
      ENSP00000328631.2, ENST00000330154.6
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    18. XM_017029993.1XP_016885482.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    19. XM_017029989.1XP_016885478.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    20. XM_017029995.1XP_016885484.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    21. XM_024452484.1XP_024308252.1  armadillo repeat-containing X-linked protein 2 isoform X1

      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    22. XM_017029996.1XP_016885485.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    23. XM_017029997.1XP_016885486.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q7L311
      UniProtKB/TrEMBL
      A0A024RCG7
      Conserved Domains (3) summary
      sd00044
      Location:391416
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:377626
      Arm_2; Armadillo-like
      cl26386
      Location:39279
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
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