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    Dcaf8 DDB1 and CUL4 associated factor 8 [ Mus musculus (house mouse) ]

    Gene ID: 98193, updated on 5-Aug-2018

    Summary

    Official Symbol
    Dcaf8provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 8provided by MGI
    Primary source
    MGI:MGI:91860
    See related
    Ensembl:ENSMUSG00000026554 Vega:OTTMUSG00000050094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H326; C76055; Wdr42a; D1Ucla4; AA408877; AA433120; AA792214; AU018973; D1Dau35e
    Expression
    Ubiquitous expression in bladder adult (RPKM 29.6), kidney adult (RPKM 26.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dcaf8 in Genome Data Viewer
    Location:
    1 H3; 1 79.54 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (172148015..172196393)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (174078146..174126524)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene phosphoprotein enriched in astrocytes 15A Neighboring gene predicted gene 17224 Neighboring gene calsequestrin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38511

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 8
    Names
    WD repeat domain 42A
    WD repeat-containing protein 42A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357204.1NP_001344133.1  DDB1- and CUL4-associated factor 8

      Status: VALIDATED

      Source sequence(s)
      AC074310
      Conserved Domains (3) summary
      sd00039
      Location:192228
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:183500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl27511
      Location:17177
      Na_Ca_ex; Sodium/calcium exchanger protein
    2. NM_153555.2NP_705783.1  DDB1- and CUL4-associated factor 8

      See identical proteins and their annotated locations for NP_705783.1

      Status: VALIDATED

      Source sequence(s)
      AC074310, AK146825, AW047778, BB851975
      Consensus CDS
      CCDS15509.1
      UniProtKB/Swiss-Prot
      Q8N7N5
      Related
      ENSMUSP00000141731.1, OTTMUSP00000068741, ENSMUST00000191689.5, OTTMUST00000127396
      Conserved Domains (3) summary
      sd00039
      Location:192228
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:183500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl27511
      Location:17177
      Na_Ca_ex; Sodium/calcium exchanger protein

    RNA

    1. NR_151641.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC074310

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      172148015..172196393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238889.2XP_011237191.1  DDB1- and CUL4-associated factor 8 isoform X1

      See identical proteins and their annotated locations for XP_011237191.1

      UniProtKB/Swiss-Prot
      Q8N7N5
      Related
      ENSMUSP00000073778.5, OTTMUSP00000068743, ENSMUST00000074144.10, OTTMUST00000127399
      Conserved Domains (3) summary
      sd00039
      Location:192228
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:183500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl27511
      Location:17177
      Na_Ca_ex; Sodium/calcium exchanger protein
    2. XM_006497065.3XP_006497128.1  DDB1- and CUL4-associated factor 8 isoform X1

      UniProtKB/Swiss-Prot
      Q8N7N5
      Related
      ENSMUSP00000141732.1, OTTMUSP00000068742, ENSMUST00000192704.5, OTTMUST00000127398
      Conserved Domains (3) summary
      sd00039
      Location:192228
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:183500
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl27511
      Location:17177
      Na_Ca_ex; Sodium/calcium exchanger protein
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