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    GIT2 GIT ArfGAP 2 [ Homo sapiens (human) ]

    Gene ID: 9815, updated on 7-Jul-2024

    Summary

    Official Symbol
    GIT2provided by HGNC
    Official Full Name
    GIT ArfGAP 2provided by HGNC
    Primary source
    HGNC:HGNC:4273
    See related
    Ensembl:ENSG00000139436 MIM:608564; AllianceGenome:HGNC:4273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKL; CAT2; CAT-2
    Summary
    This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 15.0), lymph node (RPKM 13.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GIT2 in Genome Data Viewer
    Location:
    12q24.11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (109929804..110000164, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (109905496..109975853, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110367609..110434173, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 441, pseudogene Neighboring gene glycolipid transfer protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4845 Neighboring gene uncharacterized LOC124903012 Neighboring gene NANOG hESC enhancer GRCh37_chr12:110318928-110319429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4847 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110337802-110338642 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:110338643-110339483 Neighboring gene trichoplein keratin filament binding Neighboring gene ReSE screen-validated silencer GRCh37_chr12:110353916-110354160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110358257-110358757 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110361416-110362271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110362776-110363756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:110363757-110364736 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:110370433-110371632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110384533-110385204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:110385205-110385876 Neighboring gene uncharacterized LOC124903013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6990 Neighboring gene Sharpr-MPRA regulatory region 2512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6991 Neighboring gene ankyrin repeat domain 13A Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110460576-110461076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:110465819-110467018 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:110480304-110480817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6993 Neighboring gene chromosome 12 open reading frame 76 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6995 Neighboring gene CRISPRi-validated cis-regulatory element chr12.3588 Neighboring gene uncharacterized LOC105369976 Neighboring gene Sharpr-MPRA regulatory region 13461

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of the metabolic syndrome in Indian Asian men.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC760, KIAA0148, DKFZp686G01261

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of ARF protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in focal adhesion HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ARF GTPase-activating protein GIT2
    Names
    ARF GAP GIT2
    G protein-coupled receptor kinase interacting ArfGAP 2
    G protein-coupled receptor kinase-interactor 2
    GRK-interacting protein 2
    Paxillin kinase linker
    cool-associated, tyrosine phosphorylated protein 2
    cool-interacting tyrosine-phosphorylated protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029885.1 RefSeqGene

      Range
      5022..71586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135213.3NP_001128685.1  ARF GTPase-activating protein GIT2 isoform 6

      See identical proteins and their annotated locations for NP_001128685.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons in the 3' coding region and includes an additional short in-frame exon in the central coding region, compared to isoform 1. The resulting isoform (6) is missing two internal fragments and includes a 2 residue insertion, compared to isoform 1.
      Source sequence(s)
      AA813937, BP871813, D63482
      Consensus CDS
      CCDS55884.1
      UniProtKB/TrEMBL
      R4GNG3
      Related
      ENSP00000391813.2, ENST00000457474.6
      Conserved Domains (5) summary
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:563674
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_001135214.3NP_001128686.1  ARF GTPase-activating protein GIT2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks one in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (5) is missing one fragment but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA813937, AF124491, BP871813, CR749340, D63482
      Consensus CDS
      CCDS44968.1
      UniProtKB/TrEMBL
      R4GNG3
      Related
      ENSP00000354282.5, ENST00000361006.9
      Conserved Domains (7) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:608722
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    3. NM_001330153.2NP_001317082.1  ARF GTPase-activating protein GIT2 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (7) is shorter but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA813937, AF124491, BE646544, BP871813, CR980157, D63482
      Consensus CDS
      CCDS81736.1
      UniProtKB/TrEMBL
      F8VXI9, R4GNG3
      Related
      ENSP00000448832.1, ENST00000551209.5
      Conserved Domains (6) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:265293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:587701
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    4. NM_001330154.2NP_001317083.1  ARF GTPase-activating protein GIT2 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks most 3' exons and has an alternate exon at the 3' end, as compared to variant 1. Isoform 8 is much shorter and has a different C-terminus than isoform 1.
      Source sequence(s)
      AC084876, AK222736, BM557270, BP871813
      Consensus CDS
      CCDS81737.1
      UniProtKB/TrEMBL
      B4E2E7, F8W822
      Related
      ENSP00000323833.9, ENST00000320063.10
      Conserved Domains (4) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:266293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
    5. NM_014776.5NP_055591.2  ARF GTPase-activating protein GIT2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two exons in the coding region, as compared to variant 1. Isoform 3 is missing two fragments but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA813937, AF124491, BP871813, D63482
      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (6) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:558672
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    6. NM_057169.5NP_476510.1  ARF GTPase-activating protein GIT2 isoform 1

      See identical proteins and their annotated locations for NP_476510.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA813937, AF124491, BP871813, D63482
      Consensus CDS
      CCDS9138.1
      UniProtKB/Swiss-Prot
      Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2
      UniProtKB/TrEMBL
      R4GNG3
      Related
      ENSP00000347464.3, ENST00000355312.8
      Conserved Domains (7) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:638752
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    7. NM_057170.5NP_476511.1  ARF GTPase-activating protein GIT2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons and a portion of a third exon in the coding region, as compared to variant 1. The reading frame is maintained. Isoform 2 is missing internal 128 aa but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA813937, AK308304, BC014223, BP871813, D63482
      Consensus CDS
      CCDS44969.1
      UniProtKB/TrEMBL
      R4GNG3
      Related
      ENSP00000447465.1, ENST00000553118.5
      Conserved Domains (6) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
      pfam08518
      Location:266293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:510624
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam16559
      Location:414450
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    8. NM_139201.3NP_631940.2  ARF GTPase-activating protein GIT2 isoform 4

      See identical proteins and their annotated locations for NP_631940.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks most 3' exons and has an alternate exon at the 3' end, as compared to variant 1. Isoform 4 is much shorter and has a different C-terminus than isoform 1.
      Source sequence(s)
      AC084876, AK222736, BM557270, BP871813
      Consensus CDS
      CCDS9139.1
      UniProtKB/TrEMBL
      B5BU58, Q6FI58
      Related
      ENSP00000450348.1, ENST00000547815.5
      Conserved Domains (6) summary
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414465
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      pfam14203
      Location:246284
      TTRAP; Putative tranposon-transfer assisting protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      109929804..110000164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429924.1XP_047285880.1  ARF GTPase-activating protein GIT2 isoform X8

      UniProtKB/TrEMBL
      R4GNG3
    2. XM_047429926.1XP_047285882.1  ARF GTPase-activating protein GIT2 isoform X10

      UniProtKB/TrEMBL
      R4GNG3
    3. XM_047429925.1XP_047285881.1  ARF GTPase-activating protein GIT2 isoform X9

      UniProtKB/TrEMBL
      R4GNG3
    4. XM_017020258.3XP_016875747.1  ARF GTPase-activating protein GIT2 isoform X6

      UniProtKB/TrEMBL
      R4GNG3
    5. XM_047429922.1XP_047285878.1  ARF GTPase-activating protein GIT2 isoform X3

      UniProtKB/TrEMBL
      R4GNG3
    6. XM_047429923.1XP_047285879.1  ARF GTPase-activating protein GIT2 isoform X4

      UniProtKB/TrEMBL
      R4GNG3
    7. XM_005253997.5XP_005254054.1  ARF GTPase-activating protein GIT2 isoform X1

      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (7) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:265293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:637751
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:413477
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    8. XM_006719712.5XP_006719775.1  ARF GTPase-activating protein GIT2 isoform X11

      Conserved Domains (6) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:475589
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    9. XM_006719709.5XP_006719772.1  ARF GTPase-activating protein GIT2 isoform X7

      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (6) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:588702
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    10. XM_006719708.5XP_006719771.1  ARF GTPase-activating protein GIT2 isoform X5

      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (7) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:593707
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414463
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    11. XM_006719707.5XP_006719770.1  ARF GTPase-activating protein GIT2 isoform X2

      UniProtKB/TrEMBL
      R4GNG3
      Conserved Domains (7) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:623737
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414463
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    12. XM_047429928.1XP_047285884.1  ARF GTPase-activating protein GIT2 isoform X15

      UniProtKB/TrEMBL
      B4E2E7
    13. XM_047429927.1XP_047285883.1  ARF GTPase-activating protein GIT2 isoform X14

      UniProtKB/TrEMBL
      B5BU58
    14. XM_017020261.3XP_016875750.1  ARF GTPase-activating protein GIT2 isoform X12

      UniProtKB/TrEMBL
      B5BU58
    15. XM_006719713.5XP_006719776.1  ARF GTPase-activating protein GIT2 isoform X13

      UniProtKB/TrEMBL
      B5BU58
      Conserved Domains (6) summary
      smart00105
      Location:2124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414449
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      109905496..109975853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373915.1XP_054229890.1  ARF GTPase-activating protein GIT2 isoform X8

      UniProtKB/TrEMBL
      R4GNG3
    2. XM_054373917.1XP_054229892.1  ARF GTPase-activating protein GIT2 isoform X10

      UniProtKB/TrEMBL
      R4GNG3
    3. XM_054373916.1XP_054229891.1  ARF GTPase-activating protein GIT2 isoform X9

      UniProtKB/TrEMBL
      R4GNG3
    4. XM_054373913.1XP_054229888.1  ARF GTPase-activating protein GIT2 isoform X6

      UniProtKB/TrEMBL
      R4GNG3
    5. XM_054373910.1XP_054229885.1  ARF GTPase-activating protein GIT2 isoform X3

      UniProtKB/TrEMBL
      R4GNG3
    6. XM_054373911.1XP_054229886.1  ARF GTPase-activating protein GIT2 isoform X4

      UniProtKB/TrEMBL
      R4GNG3
    7. XM_054373908.1XP_054229883.1  ARF GTPase-activating protein GIT2 isoform X1

      UniProtKB/TrEMBL
      R4GNG3
    8. XM_054373918.1XP_054229893.1  ARF GTPase-activating protein GIT2 isoform X11

    9. XM_054373914.1XP_054229889.1  ARF GTPase-activating protein GIT2 isoform X7

      UniProtKB/TrEMBL
      R4GNG3
    10. XM_054373912.1XP_054229887.1  ARF GTPase-activating protein GIT2 isoform X5

      UniProtKB/TrEMBL
      R4GNG3
    11. XM_054373909.1XP_054229884.1  ARF GTPase-activating protein GIT2 isoform X2

      UniProtKB/TrEMBL
      R4GNG3
    12. XM_054373922.1XP_054229897.1  ARF GTPase-activating protein GIT2 isoform X15

      UniProtKB/TrEMBL
      B4E2E7
    13. XM_054373921.1XP_054229896.1  ARF GTPase-activating protein GIT2 isoform X14

      UniProtKB/TrEMBL
      B5BU58
    14. XM_054373919.1XP_054229894.1  ARF GTPase-activating protein GIT2 isoform X12

      UniProtKB/TrEMBL
      B5BU58
    15. XM_054373920.1XP_054229895.1  ARF GTPase-activating protein GIT2 isoform X13

      UniProtKB/TrEMBL
      B5BU58