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    Gtf2f1 general transcription factor IIF, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 98053, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gtf2f1provided by MGI
    Official Full Name
    general transcription factor IIF, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1923848
    See related
    Ensembl:ENSMUSG00000002658
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAP74; C76800; 2810405L04Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 78.6), liver E14 (RPKM 38.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gtf2f1 in Genome Data Viewer
    Location:
    17; 17 D
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (57003401..57011423, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (57142825..57150711, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene alkB homolog 7 Neighboring gene persephin Neighboring gene adenylate kinase 5 pseudogene Neighboring gene KH-type splicing regulatory protein Neighboring gene solute carrier family 25, member 41

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    general transcription factor IIF subunit 1
    Names
    TFIIF-alpha
    general transcription factor IIF polypeptide 1 (74kD subunit)
    transcription initiation factor IIF subunit alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133801.2NP_598562.1  general transcription factor IIF subunit 1

      See identical proteins and their annotated locations for NP_598562.1

      Status: PROVISIONAL

      Source sequence(s)
      AC073683, CT571247
      Consensus CDS
      CCDS37667.1
      UniProtKB/Swiss-Prot
      Q3THK3
      Related
      ENSMUSP00000002733.6, ENSMUST00000002733.6
      Conserved Domains (1) summary
      pfam05793
      Location:2508
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      57003401..57011423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525194.3XP_006525257.1  general transcription factor IIF subunit 1 isoform X1

      Conserved Domains (2) summary
      cd00240
      Location:1144
      TFIIFa; Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...
      pfam05793
      Location:1480
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
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