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Envelope surface glycoprotein gp120
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env
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Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection |
PubMed
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env
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Overexpression of CD81 and CD9 renders cells less susceptible to HIV-1 gp120/gp41-mediated syncytia formation; antibodies raised against CD9 and CD81 enhance syncytia formation |
PubMed
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env
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CD81 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles |
PubMed
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Envelope surface glycoprotein gp160, precursor
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env
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HIV-1 Env co-localizes with the lipid raft marker CD55 or the tetraspanin CD81 in HeLa P4-R5 cells |
PubMed
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Nef
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nef
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HIV-1 Nef is detected in detergent-insoluble AChE+/CD81 low/TSG101 low exosomes, but not in detergent-soluble AChE-/CD81 high/TSG101 high exosomes in Nef-transfected 293T cells |
PubMed
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nef
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Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD81 (TSPAN28) |
PubMed
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nef
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HIV-1 Nef increases the production of exosomes, which form at the plasma membrane and co-localizes with plasma membrane-associated proteins ICAM1, CD81, and Lck in Jurkat |
PubMed
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Pr55(Gag)
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gag
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Co-localization of HIV-1 Gag virus-like particles in THP-1/CD169YF cells is reduced within CD81+ compartments, but enhanced within CD63+ or LAMP1+ compartments |
PubMed
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gag
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HIV-1 Gag proteins co-localize with CD63 and CD81 in intracellular exosomes |
PubMed
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gag
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HIV-1 Gag recruits and traps CD81 to Gag assembly sites at the plasma membrane |
PubMed
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gag
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HIV-1 Gag P99A mutation reduces its co-localization with tetraspanin-enriched microdomain marker CD81 and lipid raft marker CD59 |
PubMed
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gag
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Tetherin co-localizes with HIV-1 Gag in CD81- and CD63-enriched intracellular virus-containing compartments in macrophages, and that a separate population of tetherin is located in the TGN |
PubMed
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gag
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In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding |
PubMed
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Vpu
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vpu
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HIV-1 Vpu co-localizes with CD81 in HIV-1-infected CEMss T cells |
PubMed
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vpu
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Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD81 (TSPAN28) |
PubMed
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capsid
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gag
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Infection of monocyte-derived macrophages with HIV-1 redistributes viperin from ER into foci, which significantly co-localizes with p24 and CD81 |
PubMed
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matrix
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gag
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In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding |
PubMed
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