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    SLK STE20 like kinase [ Homo sapiens (human) ]

    Gene ID: 9748, updated on 5-May-2024

    Summary

    Official Symbol
    SLKprovided by HGNC
    Official Full Name
    STE20 like kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:11088
    See related
    Ensembl:ENSG00000065613 MIM:616563; AllianceGenome:HGNC:11088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LOSK; STK2; se20-9; bA16H23.1
    Summary
    Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in esophagus (RPKM 35.4), lung (RPKM 15.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10q24.33-q25.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103967140..104029233)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (104854380..104916616)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105726898..105788991)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene STN1 subunit of CST complex Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105667461-105668062 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 10:105668179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105677593-105678238 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105686883-105687548 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105688215-105688880 Neighboring gene uncharacterized LOC102724351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105730769-105731270 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105731271-105731770 Neighboring gene RNA, 7SL, cytoplasmic 524, pseudogene Neighboring gene collagen type XVII alpha 1 chain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105812840-105813426 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:105813739-105814938 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105826696-105827351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105827352-105828006 Neighboring gene microRNA 936 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:105879992-105881191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105881347-105882010 Neighboring gene SWI5 dependent homologous recombination repair protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0204, MGC133067

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadherin binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    STE20-like serine/threonine-protein kinase
    Names
    CTCL tumor antigen se20-9
    Long Ste20-like Kinase
    SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase
    SNF1 sucrose nonfermenting like kinase
    STE20-related kinase
    STE20-related serine/threonine-protein kinase
    Ste20-related serine/threonine kinase
    hSLK
    serine/threonine-protein kinase 2
    NP_001291672.1
    NP_055535.2
    XP_011538703.1
    XP_047281995.1
    XP_054223219.1
    XP_054223220.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304743.2NP_001291672.1  STE20-like serine/threonine-protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001291672.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a shorter isoform (2) compared to isoform 1.
      Source sequence(s)
      AL138761, AL360170, BC008697, BC047885, BC111565
      Consensus CDS
      CCDS76334.1
      UniProtKB/TrEMBL
      B4DZC9
      Related
      ENSP00000336824.4, ENST00000335753.8
      Conserved Domains (3) summary
      smart00220
      Location:34292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:9891129
      PKK; Polo kinase kinase
    2. NM_014720.4NP_055535.2  STE20-like serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_055535.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF273048, AL138761, AL360170, BC047885
      Consensus CDS
      CCDS7553.1
      UniProtKB/Swiss-Prot
      D3DRA0, D3DRA1, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9H2G2, Q9NQL0, Q9NQL1
      UniProtKB/TrEMBL
      B4DZC9
      Related
      ENSP00000358770.3, ENST00000369755.4
      Conserved Domains (3) summary
      smart00220
      Location:34292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:10201160
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      103967140..104029233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540401.4XP_011538703.1  STE20-like serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:34292
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06643
      Location:28309
      STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase
      pfam12474
      Location:568708
      PKK; Polo kinase kinase
    2. XM_047426039.1XP_047281995.1  STE20-like serine/threonine-protein kinase isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      104854380..104916616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367244.1XP_054223219.1  STE20-like serine/threonine-protein kinase isoform X1

    2. XM_054367245.1XP_054223220.1  STE20-like serine/threonine-protein kinase isoform X2