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    CD79B CD79b molecule [ Homo sapiens (human) ]

    Gene ID: 974, updated on 11-Jun-2021

    Summary

    Official Symbol
    CD79Bprovided by HGNC
    Official Full Name
    CD79b moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1699
    See related
    Ensembl:ENSG00000007312 MIM:147245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B29; IGB; AGM6
    Summary
    The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lymph node (RPKM 118.7), spleen (RPKM 71.5) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CD79B in Genome Data Viewer
    Location:
    17q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (63928740..63932331, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62006100..62009691, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268204 Neighboring gene IGHD type 1A-2 recombination region Neighboring gene growth hormone locus control region Neighboring gene growth hormone 1 Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC105371858 Neighboring gene PRR29 antisense RNA 1 Neighboring gene proline rich 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Agammaglobulinemia 6, autosomal recessive
    MedGen: C3150207 OMIM: 612692 GeneReviews: Not available
    Compare labs
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates CD79B from the surface of dual-positive CD79b/CD20 B cells PubMed
    env SDF-1alpha reverses gp120-induced downregulation of CD79b in CD40- and IL-4-activated purified HIV-1 seronegative human peripheral blood B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of B cell receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    B-cell antigen receptor complex-associated protein beta chain
    Names
    B-cell-specific glycoprotein B29
    CD79b antigen (immunoglobulin-associated beta)
    CD79b molecule, immunoglobulin-associated beta
    Ig-beta
    immunoglobulin-associated B29 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007368.1 RefSeqGene

      Range
      5001..8607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_43

    mRNA and Protein(s)

    1. NM_000626.4NP_000617.1  B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_000617.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. The encoded isoform (1) is shorter compared to isoform 3, but has identical N- and C- termini.
      Source sequence(s)
      AA804163, AC127029, M89957
      Consensus CDS
      CCDS11655.1
      UniProtKB/Swiss-Prot
      P40259
      Related
      ENSP00000006750.4, ENST00000006750.8
      Conserved Domains (2) summary
      smart00077
      Location:193212
      ITAM; Immunoreceptor tyrosine-based activation motif
      cd16096
      Location:51142
      IgV_CD79b_beta; Immunoglobulin variable domain (IgV)
    2. NM_001039933.3NP_001035022.1  B-cell antigen receptor complex-associated protein beta chain isoform 3 precursor

      See identical proteins and their annotated locations for NP_001035022.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AK222954
      Consensus CDS
      CCDS42372.1
      UniProtKB/Swiss-Prot
      P40259
      Related
      ENSP00000376544.3, ENST00000392795.7
      Conserved Domains (3) summary
      smart00077
      Location:194213
      ITAM; Immunoreceptor tyrosine-based activation motif
      smart00410
      Location:51143
      IG_like; Immunoglobulin like
      pfam07686
      Location:49143
      V-set; Immunoglobulin V-set domain
    3. NM_001329050.2NP_001315979.1  B-cell antigen receptor complex-associated protein beta chain isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in its 5' coding region compared to variant 3. The encoded isoform (4) is shorter than isoform 3.
      Source sequence(s)
      AC127029
      Conserved Domains (1) summary
      smart00077
      Location:90109
      ITAM; Immunoreceptor tyrosine-based activation motif
    4. NM_021602.4NP_067613.1  B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_067613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and also lacks an exon in the coding region, compared to variant 3. The encoded isoform (2) is shorter compared to isoform 3, but has identical N- and C- termini.
      Source sequence(s)
      AK222954, M89957, X83539
      Consensus CDS
      CCDS11656.1
      UniProtKB/Swiss-Prot
      P40259
      Related
      ENSP00000245862.2, ENST00000349817.2
      Conserved Domains (1) summary
      smart00077
      Location:89108
      ITAM; Immunoreceptor tyrosine-based activation motif

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      63928740..63932331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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