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    USP34 ubiquitin specific peptidase 34 [ Homo sapiens (human) ]

    Gene ID: 9736, updated on 2-May-2024

    Summary

    Official Symbol
    USP34provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 34provided by HGNC
    Primary source
    HGNC:HGNC:20066
    See related
    Ensembl:ENSG00000115464 MIM:615295; AllianceGenome:HGNC:20066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 17.6), lymph node (RPKM 17.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    2p15
    Exon count:
    80
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (61187463..61471087, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (61193315..61476925, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (61414598..61698222, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:61371323-61372244 Neighboring gene C2orf74 divergent transcript Neighboring gene C2orf74 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61395441-61395942 Neighboring gene chromosome 2 open reading frame 74 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:61407627-61408205 Neighboring gene activator of HSP90 ATPase homolog 2, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13579 Neighboring gene BNIP3 pseudogene 45 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:61504619-61505818 Neighboring gene NANOG hESC enhancer GRCh37_chr2:61607882-61608383 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:61644005-61644197 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:61652307-61652984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:61652985-61653662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61653663-61654340 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:61657175-61657369 Neighboring gene small nucleolar RNA, H/ACA box 70B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11526 Neighboring gene MPRA-validated peak3715 silencer Neighboring gene Sharpr-MPRA regulatory region 6736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61692432-61692952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61692953-61693472 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:61694001-61694500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11529 Neighboring gene MPRA-validated peak3716 silencer Neighboring gene USP34 divergent transcript Neighboring gene MPRA-validated peak3717 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61743599-61744099 Neighboring gene exportin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15833 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:61766044-61766833 Neighboring gene proteasome 26S subunit, non-ATPase 12 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ43910, KIAA0570, KIAA0729, MGC104459

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    enables cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 34
    Names
    deubiquitinating enzyme 34
    ubiquitin specific protease 34
    ubiquitin thioesterase 34
    ubiquitin thiolesterase 34
    ubiquitin-specific-processing protease 34
    NP_055524.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014709.4NP_055524.3  ubiquitin carboxyl-terminal hydrolase 34

      See identical proteins and their annotated locations for NP_055524.3

      Status: VALIDATED

      Source sequence(s)
      AB011142, AC016727, AC016894, AC018889, AK023171, AW293998, BX473680
      Consensus CDS
      CCDS42686.1
      UniProtKB/Swiss-Prot
      A8MWD0, B3KWU9, O60316, O94834, Q3B777, Q6P6C9, Q70CQ2, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1
      Related
      ENSP00000381577.2, ENST00000398571.7
      Conserved Domains (2) summary
      cd02659
      Location:18922241
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:18942236
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      61187463..61471087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      61193315..61476925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)