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    Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [ Mus musculus (house mouse) ]

    Gene ID: 97212, updated on 16-Oct-2021

    Summary

    Official Symbol
    Hadhaprovided by MGI
    Official Full Name
    hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alphaprovided by MGI
    Primary source
    MGI:MGI:2135593
    See related
    Ensembl:ENSMUSG00000025745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtpa; C77020; TP-alpha
    Expression
    Ubiquitous expression in heart adult (RPKM 149.0), liver E18 (RPKM 62.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hadha in Genome Data Viewer
    Location:
    5; 5 B1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30324421..30359978, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30119423..30154980, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30444844..30481520, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082J24 gene Neighboring gene kinesin superfamily protein 2C pseudogene Neighboring gene kinesin family member 2C pseudogene Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene microRNA 1960 Neighboring gene adhesion G protein-coupled receptor F3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetyl-CoA C-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enoyl-CoA hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enoyl-CoA hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enoyl-CoA hydratase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain-enoyl-CoA hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cardiolipin acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    trifunctional enzyme subunit alpha, mitochondrial
    Names
    hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
    monolysocardiolipin acyltransferase
    NP_849209.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178878.3NP_849209.1  trifunctional enzyme subunit alpha, mitochondrial precursor

      See identical proteins and their annotated locations for NP_849209.1

      Status: VALIDATED

      Source sequence(s)
      AK029017
      Consensus CDS
      CCDS19155.1
      UniProtKB/Swiss-Prot
      Q8BMS1
      Related
      ENSMUSP00000120976.2, ENSMUST00000156859.3
      Conserved Domains (1) summary
      TIGR02441
      Location:27762
      fa_ox_alpha_mit; fatty acid oxidation complex, alpha subunit, mitochondrial

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      30324421..30359978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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