Format

Send to:

Choose Destination
    • Showing Current items.

    Hist2h4 histone cluster 2, H4 [ Mus musculus (house mouse) ]

    Gene ID: 97122, updated on 31-Jan-2019

    Summary

    Official Symbol
    Hist2h4provided by MGI
    Official Full Name
    histone cluster 2, H4provided by MGI
    Primary source
    MGI:MGI:2140113
    See related
    Ensembl:ENSMUSG00000091405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H4; X04652
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. [provided by RefSeq, Aug 2015]

    Genomic context

    See Hist2h4 in Genome Data Viewer
    Location:
    3; 3 F2.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (96262934..96263317, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (96066893..96067240, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene histone cluster 2, H3c1 Neighboring gene predicted gene 20627 Neighboring gene histone cluster 2, H3b Neighboring gene histone cluster 2, H2bb

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the Hist2h4 gene: The Hist2h4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
    • Orthologs

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA replication-dependent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication-independent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone H4
    Names
    histone 2, H4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033596.3NP_291074.1  histone H4

      See identical proteins and their annotated locations for NP_291074.1

      Status: REVIEWED

      Source sequence(s)
      AC125099
      Consensus CDS
      CCDS51002.1
      UniProtKB/Swiss-Prot
      P62806
      UniProtKB/TrEMBL
      B2RTM0
      Related
      ENSMUSP00000129930.1, ENSMUST00000171473.2
      Conserved Domains (1) summary
      PLN00035
      Location:1103
      PLN00035; histone H4; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      96262934..96263317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center