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    CD70 CD70 molecule [ Homo sapiens (human) ]

    Gene ID: 970, updated on 8-Jul-2021

    Summary

    Official Symbol
    CD70provided by HGNC
    Official Full Name
    CD70 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:11937
    See related
    Ensembl:ENSG00000125726 MIM:602840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD27L; LPFS3; CD27-L; CD27LG; TNFSF7; TNLG8A
    Summary
    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See CD70 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6581648..6591150, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6581659..6591161, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transforming growth factor beta receptor 1 pseudogene Neighboring gene chloride intracellular channel 4 pseudogene 2 Neighboring gene ribosomal protein L7 pseudogene 50 Neighboring gene TNF superfamily member 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    CD70 antigen
    Names
    CD27 ligand
    Ki-24 antigen
    surface antigen CD70
    tumor necrosis factor ligand 8A
    tumor necrosis factor ligand superfamily member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252.5NP_001243.1  CD70 antigen isoform 1

      See identical proteins and their annotated locations for NP_001243.1

      Status: REVIEWED

      Source sequence(s)
      AC008760, KC877696
      Consensus CDS
      CCDS12170.1
      UniProtKB/Swiss-Prot
      P32970
      UniProtKB/TrEMBL
      A0A0U5JA32
      Related
      ENSP00000245903.2, ENST00000245903.4
      Conserved Domains (1) summary
      smart00207
      Location:73191
      TNF; Tumour necrosis factor family
    2. NM_001330332.2NP_001317261.1  CD70 antigen isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC008760, AK298467
      Consensus CDS
      CCDS82283.1
      UniProtKB/Swiss-Prot
      P32970
      Related
      ENSP00000395294.2, ENST00000423145.7

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      6581648..6591150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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