U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TTLL4 tubulin tyrosine ligase like 4 [ Homo sapiens (human) ]

    Gene ID: 9654, updated on 17-Jun-2024

    Summary

    Official Symbol
    TTLL4provided by HGNC
    Official Full Name
    tubulin tyrosine ligase like 4provided by HGNC
    Primary source
    HGNC:HGNC:28976
    See related
    Ensembl:ENSG00000135912 MIM:618738; AllianceGenome:HGNC:28976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within regulation of blastocyst development. Predicted to be located in cytosol. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 10.4), brain (RPKM 3.1) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TTLL4 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218710835..218759724)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219197391..219244038)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219575558..219620139)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17128 Neighboring gene ring finger protein 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12324 Neighboring gene serine/threonine kinase 36 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:219563769-219564269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17129 Neighboring gene uncharacterized LOC124907983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12326 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:219584289-219584586 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:219609538-219610737 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:219611731-219612930 Neighboring gene cytochrome P450 family 27 subfamily A member 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:219687585-219688784 Neighboring gene microRNA 9500 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0173

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-glutamic acid ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin-glutamic acid ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tubulin-glutamic acid ligase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-glutamic acid modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of blastocyst development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tubulin monoglutamylase TTLL4
    Names
    protein monoglutamylase TTLL4
    tubulin polyglutamylase TTLL4
    tubulin tyrosine ligase-like family, member 4
    tubulin--tyrosine ligase-like protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014640.5NP_055455.3  tubulin monoglutamylase TTLL4

      See identical proteins and their annotated locations for NP_055455.3

      Status: VALIDATED

      Source sequence(s)
      AC009974, AK291770, DB097392
      Consensus CDS
      CCDS2422.1
      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
      Related
      ENSP00000375951.1, ENST00000392102.6
      Conserved Domains (1) summary
      pfam03133
      Location:654946
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      218710835..218759724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446455.1XP_047302411.1  tubulin monoglutamylase TTLL4 isoform X4

      UniProtKB/TrEMBL
      E7EX20
    2. XM_047446454.1XP_047302410.1  tubulin monoglutamylase TTLL4 isoform X3

      UniProtKB/TrEMBL
      E7EX20
    3. XM_006712875.3XP_006712938.1  tubulin monoglutamylase TTLL4 isoform X4

      UniProtKB/TrEMBL
      E7EX20
      Conserved Domains (1) summary
      pfam03133
      Location:654946
      TTL; Tubulin-tyrosine ligase family
    4. XM_047446456.1XP_047302412.1  tubulin monoglutamylase TTLL4 isoform X4

      UniProtKB/TrEMBL
      E7EX20
    5. XM_047446457.1XP_047302413.1  tubulin monoglutamylase TTLL4 isoform X4

      UniProtKB/TrEMBL
      E7EX20
      Related
      ENSP00000393332.1, ENST00000457313.5
    6. XM_017005388.2XP_016860877.1  tubulin monoglutamylase TTLL4 isoform X1

      UniProtKB/TrEMBL
      E7EX20
    7. XM_047446452.1XP_047302408.1  tubulin monoglutamylase TTLL4 isoform X2

      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
    8. XM_017005387.2XP_016860876.1  tubulin monoglutamylase TTLL4 isoform X1

      UniProtKB/TrEMBL
      E7EX20
    9. XM_047446453.1XP_047302409.1  tubulin monoglutamylase TTLL4 isoform X2

      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
    10. XM_017005390.2XP_016860879.1  tubulin monoglutamylase TTLL4 isoform X1

      UniProtKB/TrEMBL
      E7EX20
    11. XM_047446450.1XP_047302406.1  tubulin monoglutamylase TTLL4 isoform X2

      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
    12. XM_017005391.2XP_016860880.1  tubulin monoglutamylase TTLL4 isoform X1

      UniProtKB/TrEMBL
      E7EX20
    13. XM_047446451.1XP_047302407.1  tubulin monoglutamylase TTLL4 isoform X2

      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
      Related
      ENSP00000258398.4, ENST00000258398.8
    14. XM_047446459.1XP_047302415.1  tubulin monoglutamylase TTLL4 isoform X5

    15. XM_047446458.1XP_047302414.1  tubulin monoglutamylase TTLL4 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      219197391..219244038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344685.1XP_054200660.1  tubulin monoglutamylase TTLL4 isoform X4

      UniProtKB/TrEMBL
      E7EX20
    2. XM_054344683.1XP_054200658.1  tubulin monoglutamylase TTLL4 isoform X3

      UniProtKB/TrEMBL
      E7EX20
    3. XM_054344684.1XP_054200659.1  tubulin monoglutamylase TTLL4 isoform X4

      UniProtKB/TrEMBL
      E7EX20
    4. XM_054344686.1XP_054200661.1  tubulin monoglutamylase TTLL4 isoform X4

      UniProtKB/TrEMBL
      E7EX20
    5. XM_054344687.1XP_054200662.1  tubulin monoglutamylase TTLL4 isoform X4

      UniProtKB/TrEMBL
      E7EX20
    6. XM_054344678.1XP_054200653.1  tubulin monoglutamylase TTLL4 isoform X1

      UniProtKB/TrEMBL
      E7EX20
    7. XM_054344681.1XP_054200656.1  tubulin monoglutamylase TTLL4 isoform X2

      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
    8. XM_054344675.1XP_054200650.1  tubulin monoglutamylase TTLL4 isoform X1

      UniProtKB/TrEMBL
      E7EX20
    9. XM_054344682.1XP_054200657.1  tubulin monoglutamylase TTLL4 isoform X2

      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
    10. XM_054344676.1XP_054200651.1  tubulin monoglutamylase TTLL4 isoform X1

      UniProtKB/TrEMBL
      E7EX20
    11. XM_054344679.1XP_054200654.1  tubulin monoglutamylase TTLL4 isoform X2

      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
    12. XM_054344677.1XP_054200652.1  tubulin monoglutamylase TTLL4 isoform X1

      UniProtKB/TrEMBL
      E7EX20
    13. XM_054344680.1XP_054200655.1  tubulin monoglutamylase TTLL4 isoform X2

      UniProtKB/Swiss-Prot
      A8K6V5, Q14679, Q8WW29
      UniProtKB/TrEMBL
      E7EX20
    14. XM_054344689.1XP_054200664.1  tubulin monoglutamylase TTLL4 isoform X5

    15. XM_054344688.1XP_054200663.1  tubulin monoglutamylase TTLL4 isoform X5